{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T08:28:40Z","timestamp":1719822520811},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T00:00:00Z","timestamp":1158537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To compare the ocular hypotensive efficacy and safety of topical bimatoprost and timolol\u2010dorzolamide combination in patients with primary open\u2010angle glaucoma (POAG) or ocular hypertension during 6\u2003months of treatment.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A sample of 65 patients with a diagnosis of POAG or ocular hypertension were randomized to receive either bimatoprost 0.03% once daily or timolol\u2010dorzolamide combination twice daily. Study visits occurred at baseline and after 2\u2003weeks and 1, 3 and 6\u2003months of therapy. Intraocular pressure (IOP) measurements were performed at 12.00\u2003hours at all study visits and also at 08.00\u2003hours and 16.00\u2003hours at baseline and 6\u2010month visits. At each visit, local and systemic side\u2010effects that occurred during the treatment period were recorded. Student's <jats:italic>t<\/jats:italic>\u2010test was used to compare the differences between IOP values.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Differences in IOP between the bimatoprost and timolol\u2010dorzolamide groups were statistically insignificant at all study visits (p\u2003&gt;\u20030.05). In the bimatoprost\u2010treated group, the IOP reduction was 6.2\u2003\u00b1\u20031.8\u2003mmHg, whereas it was 6.5\u2003\u00b1\u20032.3\u2003mmHg in the timolol\u2010dorzolamide group after 6\u2003months of treatment. The difference was not statistically significant (p\u2003=\u20030.48).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The IOP\u2010lowering efficacies of bimatoprost and timolol\u2010dorzolamide combination were similar over a 6\u2010month follow\u2010up. Both bimatoprost and the timolol\u2010dorzolamide combination were well tolerated. Bimatoprost can be used as a longterm monotherapy agent in the treatment of POAG and ocular hypertension.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2006.00754.x","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T15:17:54Z","timestamp":1158592674000},"page":"80-83","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of the ocular hypotensive effects of bimatoprost and timolol\u2010dorzolamide combination in patients with elevated intraocular pressure: a 6\u2010month study"],"prefix":"10.1111","volume":"85","author":[{"given":"Faruk","family":"Ozturk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0131tk\u0131 Samet","family":"Ermis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit Ubeyt","family":"Inan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration","volume":"130","author":"Advanced Glaucoma Intervention Study Investigators","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)91046-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00843-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00662-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210501500304"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00327-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0420.2004.0205.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.11.1249"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2003.12.014"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32295-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(83)90152-2"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00381-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30509-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)91045-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.1997.33.5.430476"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31484-3"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.1.57"}],"container-title":["Acta Ophthalmologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0420.2006.00754.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0420.2006.00754.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:51:55Z","timestamp":1696967515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0420.2006.00754.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,5]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1600-0420.2006.00754.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0420.2006.00754.x","archive":["Portico"],"relation":{},"ISSN":["1395-3907","1600-0420"],"issn-type":[{"value":"1395-3907","type":"print"},{"value":"1600-0420","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,5]]}}}