{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:04:11Z","timestamp":1793286251054,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T00:00:00Z","timestamp":1172534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>\n            <jats:italic>Purpose:<\/jats:italic>\n          \u2002<\/jats:bold> To determine the feasibility and efficacy of morphine sedation\/analgesia in the laser treatment of retinopathy of prematurity (ROP).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A retrospective study was carried out on all infants who underwent laser treatment for ROP over a 7\u2003year period. Morphine infusion commenced 6\u2003hrs prior to treatment at a rate of 10\u2003\u00b5g\/kg\/hr. This rate increased to 20\u2003\u00b5g\/kg\/hr at the start of laser treatment. Subsequent infusion rate was titrated according to tolerance of the laser and cardio and respiratory system changes and evidence of infant distress (truncal and limb movements) up to a maximum rate of 40\u2003\u00b5g\/kg\/hr. Following treatment, morphine was weaned over 6\u2003hrs. Infant ventilation status was recorded prior to and during morphine infusion and during laser treatment. The incidences of adverse cardiac or respiratory events occurring during laser treatment were determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> One hundred and nine infants treated from 1998 to 2005 were involved in the study. One hundred and thirty\u2010six treatments were performed and mean gestational age at the time of treatment was 36\u2003weeks. In 130 treatments, respiratory status remained stable and was not adversely affected. Infants were mechanically ventilated because of morphine\u2010induced apnoea during three treatments, because of poor laser tolerance during two treatments and because of post\u2010procedure apnoea in one case. In 65 treatments, minor alterations in oxygen saturation (&lt;\u200390%), bradycardia or tachycardia occurred.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This study demonstrates that morphine analgesia can be used as an alternative to general anaesthesia.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2007.00900.x","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T13:34:50Z","timestamp":1172583290000},"page":"644-647","source":"Crossref","is-referenced-by-count":23,"title":["Morphine analgesia as an alternative to general anaesthesia during laser treatment of retinopathy of prematurity"],"prefix":"10.1111","volume":"85","author":[{"given":"Caitriona","family":"Kirwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O'Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Prendergast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Twomey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0585-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42340"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1542\/peds.74.1.127","article-title":"An international classification of retinopathy of prematurity","volume":"74","author":"An International Classification of Retinopathy of Prematurity","year":"1984","journal-title":"Paediatrics"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1425"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00392-X"},{"key":"e_1_2_5_7_1","first-page":"229","article-title":"Pain in newborns","volume":"95","author":"Chroinin MN","year":"2002","journal-title":"Ir Med J"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060130517027"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01107-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.4.283"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00706.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19960901)45:5<631::AID-JNR12>3.0.CO;2-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00548.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"e_1_2_5_15_1","first-page":"723","article-title":"Anaesthesia for the premature infant","volume":"17","author":"Saab RN","year":"2004","journal-title":"Middle East J Anaesthesiol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.01101.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.9.762"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/112067219500500308","article-title":"General anaesthesia with endotracheal intubation for cryotherapy for retinopathy of prematurity","volume":"5","author":"Sullivan TJ","year":"1995","journal-title":"Eur J Ophthalmol"}],"container-title":["Acta Ophthalmologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0420.2007.00900.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0420.2007.00900.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:28:02Z","timestamp":1696969682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0420.2007.00900.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,20]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1600-0420.2007.00900.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0420.2007.00900.x","archive":["Portico"],"relation":{},"ISSN":["1395-3907","1600-0420"],"issn-type":[{"value":"1395-3907","type":"print"},{"value":"1600-0420","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,20]]}}}