{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:43:48Z","timestamp":1773153828073,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> The Diabetes Control and Complications Trial (DCCT) and UK Prospective Diabetes Study (UKPDS) have studied glycaemic control as well as other risk factors in preventing the progression of diabetic end\u2010organ disease, including diabetic retinopathy. We wished to determine to what extent a cross\u2010section of diabetes patients attending our eye clinic met the targets laid down by recent landmark studies.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We prospectively assessed 44 consecutive diabetes patients attending outpatient clinics for assessment of diabetic retinopathy. Each patient had HbA1c levels, serum cholesterol and blood pressure checked. A proforma was completed for each patient.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the 44 patients studied, 11 had type 1 diabetes mellitus (DM) and 33 had type 2 DM (11 insulin\u2010dependent DM [IDDM], 22 non\u2010insulin\u2010dependent DM [NIDDM]). The mean age of type 1 DM patients was 43\u2003years; that of type 2 DM patients was 62\u2003years. Five of 11 (46%) type 1 DM patients had poorly controlled diabetes (HbA1c\u2003&gt;\u20039%) compared with four of 33 (12%) type 2 DM patients. Overall, 27 of 44 (62%) patients were on antihypertensive medication. The prevalence of poorly controlled blood pressure (&gt;\u2003150\/85\u2003mmHg <jats:italic>treated<\/jats:italic>; &gt;\u200a160\/90\u2003mmHg <jats:italic>untreated<\/jats:italic>) was 16 of 44 (36%) patients overall, and was higher for type 2 DM patients (13\/33, 39%) than for type 1 DM patients (3\/11, 27%). Random serum cholesterol levels &gt;\u200a5.2 were found in 10 of 44 (23%) patients overall (4\/11 [36%] type 1 and 6\/33 [18%] type 2 DM patients).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Control of HbA1c, hypertension and hypercholesterolaemia can slow progression of retinopathy and other DM end\u2010points. Many of our patients were poorly controlled in terms of these risk factors. More attention should be addressed to these primary preventative factors in the management of diabetes patients.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2007.00944.x","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T11:58:38Z","timestamp":1192708718000},"page":"772-776","source":"Crossref","is-referenced-by-count":15,"title":["Glycaemic control and control of risk factors in diabetes patients in an ophthalmology clinic: what lessons have we learned from the UKPDS and DCCT studies?"],"prefix":"10.1111","volume":"85","author":[{"given":"Gareth T.","family":"Higgins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javeed","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian A.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700606"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06209-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140281004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100010054020"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diab.38.4.491","article-title":"Effect of aspirin alone and aspirin plus dipyridamole in early diabetic retinopathy. 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