{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:11:30Z","timestamp":1759813890748},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T00:00:00Z","timestamp":1178236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To evaluate the efficacy of different concentrations of triamcinolone acetonide (TA) on retinal endothelial cell proliferation in a retinopathy of prematurity (ROP) mouse model.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 24 C57BL\/J6 mice were exposed to 75% oxygen from postnatal day 7 to day 12. On day 12, 10 mice (group B) were injected with 20\u2003\u00b5g intravitreal TA (IVTA) and 14 mice (group C) were injected with 40\u2003\u00b5g IVTA in one eye. The contralateral eyes were injected with isotonic saline (control group\u2003=\u2003group A). Four non\u2010exposed mice served as negative controls (group D). The mice were killed on day 17 and the eyes removed for quantitative analysis of preretinal neovascularization. Neovascularization was quantified by counting the endothelial cell nuclei on the vitreal side of the inner limiting membrane of the retina.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The endothelial cell count per histological section was lower in groups B (1.4\u2003\u00b1\u20031.7 cells; p\u2003&lt;\u20030.00001) and C (0.9\u2003\u00b1\u20031.4 cells; p\u2003&lt;\u20030.000001) compared with the control group (group A, 17.0\u2003\u00b1\u20034.8 cells). However, there was no significant difference in cell count between groups B and C (p\u2003=\u20030.430).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Triamcinolone acetonide suppresses endothelial cell proliferation in an ROP mouse model <jats:italic>in vivo<\/jats:italic>. There is no difference between dosages of 20\u2003\u00b5g and 40\u2003\u00b5g IVTA in experimental use in the suppression rates of endothelial cell proliferation.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2007.00945.x","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T07:17:26Z","timestamp":1178695046000},"page":"791-794","source":"Crossref","is-referenced-by-count":5,"title":["Impact of triamcinolone acetonide on retinal endothelial cells in a retinopathy of prematurity mouse model"],"prefix":"10.1111","volume":"85","author":[{"given":"Imren","family":"Akkoyun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gursel","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Oto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcu","family":"Kahraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihan","family":"Haberal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonca A.","family":"Akova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312203"},{"key":"e_1_2_6_3_1","first-page":"840","article-title":"Abnormal panretinal response pattern to carbogen inhalation in experimental retinopathy of prematurity","volume":"39","author":"Berkowitz BA","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.12.1801"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.245"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10915810290169873"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(78)35693-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.5.667"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00592.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.046391"},{"key":"e_1_2_6_11_1","first-page":"532","article-title":"Proceedings of third international symposium on retinopathy of prematurity: an update on ROP from the lab to the nursery","volume":"12","author":"Lutty GA","year":"2006","journal-title":"Mol Vis"},{"key":"e_1_2_6_12_1","first-page":"1322","article-title":"Vasoproliferation in the neonatal dog model of oxygen\u2010induced retinopathy","volume":"37","author":"McLeod DS","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)93019-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.5.709"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0772"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1093>3.0.CO;2-D"},{"key":"e_1_2_6_17_1","first-page":"491","volume-title":"The Human Eye","author":"Oyster CW","year":"1999"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199412000-00007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.905"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140419009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(85)90076-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/386671a0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.10.006"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.041895ms"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/359843a0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00698.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1651-2227.2002.tb00157.x","article-title":"Pathogenesis of retinopathy of prematurity","volume":"91","author":"Smith LE","year":"2002","journal-title":"Acta Paediatr"},{"key":"e_1_2_6_28_1","first-page":"101","article-title":"Oxygen\u2010induced retinopathy in the mouse","volume":"35","author":"Smith LE","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.052563"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.031252398"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2337\/diab.44.1.11","article-title":"Retinopathy, glucose and insulin in an elderly population. 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