{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:26:52Z","timestamp":1792661212510,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T00:00:00Z","timestamp":1194480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To test the expanded polytetrafluoroethylene (ePTFE) as a new adjuvant in trabeculectomy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Consecutive glaucoma surgical inpatients were observed at the Department of Ophthalmology of Palermo University. Sixty patients (60 eyes) were randomly assigned to undergo trabeculectomy (T), trabeculectomy with mitomycin\u2010C (TMMC), with ePTFE (TG) or with mitomycin\u2010C and ePTFE (TGMMC). Postoperative visits were scheduled at 24\u2003hr, 7\u2003days, 1, 3, 6, 12, 18 and 24\u2003months. Complete success and qualified success were assessed at two target intraocular pressure (IOP) levels \u2013\u226421 and \u226417\u2003mmHg \u2013 by Kaplan\u2013Meier curves.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The postoperative IOP reduction was significant (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.01) at the endpoint in all groups, with a mean IOP of 16.9 (\u00b12.9), 16.2 (\u00b12.7), 15.3 (\u00b13.4) and 15.2 (\u00b14.3) mmHg in T, TMMC, TG and TGMMC eyes, respectively. No intergroup difference was found at either IOP targets. The Kaplan\u2013Meier curves relating to either the \u226421\u2003mmHg or the \u226417\u2003mmHg target IOP did not show significant intergroup differences for complete and qualified success rate. When ePTFE was used, a trend favouring the medium\u2010term survival rate was noted. No adverse reaction to the ePTFE was present, and no membrane extrusion or conjuctival erosion were noted in any cases. Hypotony was significantly more frequent (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.035) in groups without ePTFE. Moreover, the late MMC\u2010related complications were more frequent when MMC was applied.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Expanded polytetrafluoroethylene implant in trabeculectomy is well tolerated and could act as a filtration modulating device. Therefore, it is useful in reducing early hypotony\u2010related complications and contributes to attaining medium\u2010term IOP control that is comparable to the low\u2010dosage MMC.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2007.01036.x","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T22:04:01Z","timestamp":1194559441000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["E\u2010PTFE (Gore\u2010Tex<sup>\u00ae<\/sup>) implant with or without low\u2010dosage mitomycin\u2010C as an adjuvant in penetrating glaucoma surgery: 2\u2003year randomized clinical trial"],"prefix":"10.1111","volume":"86","author":[{"given":"Salvatore","family":"Cillino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Zeppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Casuccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Morreale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bocchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Lodato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200206000-00009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35689"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701403"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.077800"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086112"},{"key":"e_1_2_5_7_1","first-page":"CD003658","article-title":"Needling for encapsulated trabeculectomy filtering blebs","author":"Feyi\u2010Waboso A","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.062"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3928\/1542-8877-19980501-12","article-title":"Trabeculectomy with the use of amniotic membrane for uncontrollable glaucoma","volume":"29","author":"Fujishima H","year":"1998","journal-title":"Ophthalmic Surg Lasers"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199902000-00020"},{"key":"e_1_2_5_11_1","first-page":"351","article-title":"Artificial trabeculum (MESH). 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