{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:21:31Z","timestamp":1759332091935},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> We investigated whether retinal branch arteries in healthy subjects, and non\u2010treated and treated primary open\u2010angle glaucoma (POAG) patients show irregular local patterns during dynamic reaction to acute increases of different magnitudes in intraocular pressure (IOP).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Nine POAG patients and nine age\u2010matched normal volunteers were examined with the retinal vessel analyser (RVA) using a suprasystolic IOP increase (Study 1). Fourteen POAG patients and 13 age\u2010matched controls were examined using a moderate IOP increase for 100\u2003seconds (Study 2). Longitudinal arterial profiles were obtained for the chosen time intervals. The high\u2010frequency waviness (HFW) of these profiles was analysed quantitatively.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> No significant changes in HFW were found in controls in different phases of the arterial reaction. Significant increases in HFW from baseline to dilation (Study 1, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.03) and from dilation to constriction (Study 2, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) were found in POAG patients. High\u2010frequency waviness was higher in POAG patients than in controls during dilation (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) in both studies.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our results indicate a local vessel wall difference in glaucoma patients compared with age\u2010matched controls. Increasing HFW might worsen hydraulic resistance of the vessel segment to blood flow. Significant increase of arterial microirregularities in the POAG retina during vascular dilation might be an indication for vascular endothelial alterations in glaucoma, leading to impaired perfusion in response to IOP increase.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2007.01072.x","type":"journal-article","created":{"date-parts":[[2008,5,22]],"date-time":"2008-05-22T10:10:26Z","timestamp":1211451026000},"page":"424-433","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functional <i>in vivo<\/i> assessment of retinal artery microirregularities in glaucoma"],"prefix":"10.1111","volume":"86","author":[{"given":"Konstantin E.","family":"Kotliar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walthard","family":"Vilser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines M.","family":"Lanzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"198","volume-title":"Adler\u2019s Physiology of the Eye","author":"Alm A","year":"1992"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.82.1995"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00046-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1902.sp000911"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-7560(0000)9999:9999<::AID-DMRR157>3.0.CO;2-G"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(87)90050-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130193015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.7.599"},{"key":"e_1_2_6_10_1","first-page":"323","volume-title":"SPSS Version 10 Einf\u00fchrung in die moderne Datenanalyse unter Windows","author":"B\u00fchl A","year":"2002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90118-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199906000-00012"},{"key":"e_1_2_6_13_1","first-page":"398","article-title":"Corrugated arteries \u2013 an enigma","volume":"34","author":"Foster JH","year":"1968","journal-title":"Am Surg"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73703-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/apm.1964.62.4.497","article-title":"Acute hypertensive vascular disease. 2. Studies on vascular reaction patterns and permeability changes by means of vital microscopy and colloidal tracer technique","volume":"62","author":"Giese J","year":"1964","journal-title":"Acta Pathol Microbiol Scand"},{"key":"e_1_2_6_16_1","volume-title":"Primer of Biostatistics","author":"Glantz SA","year":"1999"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00016-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197711000-00005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00018-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90525-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00006.2002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00880-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.8.949"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0847-x"},{"issue":"1","key":"e_1_2_6_25_1","first-page":"469","article-title":"Retinal blood flow is influenced by age\u2010dependent microirregularities in retinal arterial walls. Biofluidmechanical simulation","volume":"47","author":"Kotliar KE","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-10354"},{"key":"e_1_2_6_27_1","first-page":"115","article-title":"Retinal artery dilation in response to different colours in chromatic flickering light","volume":"34","author":"Lanzl IM","year":"2002","journal-title":"Ophthalmic Res"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00567.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00631.x"},{"key":"e_1_2_6_30_1","first-page":"315","article-title":"Perfusion of the juxtapapillary retina and optic nerve head in acute ocular hypertension","volume":"5","author":"Michelson G","year":"1996","journal-title":"Ger J Ophthalmol"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1998.0556"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0663-3"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.88.1.54"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003470070021"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210101100404"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526.31.4.230"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490904133"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.97.2.488"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200201000-00024"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1996.0263"},{"key":"e_1_2_6_41_1","first-page":"2721","article-title":"Influence of flicker frequency on flicker\u2010induced changes of retinal vessel diameter","volume":"43","author":"Polak K","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198707000-00033"},{"key":"e_1_2_6_43_1","first-page":"34","article-title":"Autoregulation of retinal circulation in response to decrease of perfusion pressure","volume":"21","author":"Riva CE","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_44_1","first-page":"1706","article-title":"Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry","volume":"27","author":"Riva CE","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00946937"},{"key":"e_1_2_6_46_1","first-page":"722","article-title":"Retinal blood flow autoregulation in response to an acute increase in blood pressure","volume":"27","author":"Robinson F","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"e_1_2_6_47_1","first-page":"188","article-title":"Mediators of the neuro\u2010vascular coupling in the human retina. Short\u2010time effect of intravenously administrated sodium\u2010lactate on flicker light\u2010induced vasodilation","volume":"33","author":"Schmetterer L","year":"2001","journal-title":"Ophthalmic Res"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/77.2.179"},{"key":"e_1_2_6_49_1","first-page":"114","volume-title":"Mikrozirkulation in Gehirn und Sinnesorganen","author":"Stodtmeister R","year":"1991"},{"key":"e_1_2_6_50_1","first-page":"313","volume-title":"Concepts of classical optics","author":"Strong J","year":"1958"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016926009171693"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265391"},{"key":"e_1_2_6_53_1","first-page":"1857","article-title":"Retinal capillary hemodynamics, visual\u2010evoked potentials, and pressure tolerance in normal human eyes","volume":"33","author":"Zetlan SR","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0420.2007.01072.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0420.2007.01072.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:52:09Z","timestamp":1696978329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0420.2007.01072.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1111\/j.1600-0420.2007.01072.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0420.2007.01072.x","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"2008-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}