{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:45:25Z","timestamp":1772757925299,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T00:00:00Z","timestamp":1225324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> Ophthalmic features of neurofibromatosis 2 (NF2) include juvenile cataract, retinal hamartomas and tumours of the cranial nerves. We hypothesize that these tumours lead to strabismological and neuro\u2010ophthalmological symptoms, including palsies of cranial nerves III, IV and VI, nystagmus and gaze palsies.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We carried out a retrospective review of 73 patients with known genotype. They underwent ophthalmic, neuro\u2010ophthalmological and strabismological examination. Statistical analysis was performed by calculating odds ratios and their 95% confidence intervals.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Mean best corrected visual acuity was 0.85. Strabismus was found in 38 of 73 patients (52%). A deviation based on a cranial nerve palsy was found in 16 patients (22%) and three had supranuclear palsies. Eleven of 73 patients had a nystagmus, mostly caused by peripheral\u2013vestibular disturbance. Binocular single vision was normal in 41 (58%), subnormal in six (8%) and not present in 24 (34%) patients. The average refractive error was \u2212\u20030.57\u2003D. Myopia of \u2265\u20030.5\u2003D was present in 47 (33%) eyes and hyperopia of \u2265\u20032.0\u2003D was measured in 11 (8%) eyes. In the subgroup analysis of NF2 mutation types, the relative risk for cranial nerve palsies and negative stereopsis was statistically significantly increased for the nonsense mutation group. The mosaicism group had a statistically significant decreased relative risk for concomitant squint, as did patients with unfound mutations for strabismus and poor stereopsis.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The present study is, to our knowledge, the first to examine a larger collection of NF2 patients for strabismological and neuro\u2010ophthalmological lesions. Compared with the normal population, our sample showed a higher amount of strabismus, refractive errors and an increased incidence of vestibular nystagmus.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2007.01088.x","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T16:14:27Z","timestamp":1227888867000},"page":"882-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Neurofibromatosis 2 leads to higher incidence of strabismological and neuro\u2010ophthalmological disorders"],"prefix":"10.1111","volume":"86","author":[{"given":"Matthias","family":"Feucht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Niem\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Haase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisbert","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor\u2010Felix","family":"Mautner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)91862-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.10.758"},{"key":"e_1_2_6_4_1","first-page":"75","article-title":"Genotype\u2212phenotype correlations for nervous system tumours in neurofibromatosis 2: a population\u2010based study","volume":"9","author":"Baser ME","year":"2004","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.6.354"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.3_Part_1.622"},{"key":"e_1_2_6_7_1","first-page":"34","article-title":"Zur Schielh\u00e4fugkeit und Behandlungseffizienz in Schleswig\u2010Holsten","volume":"162","author":"DeDecker W","year":"1973","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"e_1_2_6_8_1","first-page":"603","article-title":"A clinical study of type 2 neurofibromatosis","volume":"84","author":"Evans DGR","year":"1992","journal-title":"Q J Med"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.6.450"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.495"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0454-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.75.3.190"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550010065042"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1055051"},{"key":"e_1_2_6_15_1","first-page":"78","article-title":"Visusminderung bei Neurofibromatose Typ 2","volume":"1","author":"Hazim W","year":"1992","journal-title":"Ophthalmologe"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010555030"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31789-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.13.2051"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.2.109"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20138"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.10.646"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035169"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199605000-00004"},{"key":"e_1_2_6_24_1","first-page":"245","article-title":"Retinal changes associated with neurofibromatosis 2","volume":"93","author":"Meyers FA","year":"1995","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_6_25_1","first-page":"201","article-title":"Consensus Development Conference Statement on Acoustic Neuroma: December 11\u221213","volume":"1","author":"National Institute of Health","year":"1988","journal-title":"Arch Neurol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320520411"},{"key":"e_1_2_6_27_1","first-page":"529","article-title":"Germ\u2010line mutations in the neurofibromatosis 2 gene: correlations with disease severity and retinal abnormalities","volume":"59","author":"Parry DM","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612113152421"},{"key":"e_1_2_6_29_1","first-page":"224","volume-title":"Binocular Vision (Vision and Visual Dysfunction)","author":"Poggio GF","year":"1991"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72210-X"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/363515a0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90406-G"},{"key":"e_1_2_6_33_1","first-page":"245","article-title":"The orthoptic treatment of convergent squint in young children","volume":"21","author":"Worth C","year":"1901","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.1989.tb00829.x"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0420.2007.01088.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0420.2007.01088.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T13:19:19Z","timestamp":1697375959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0420.2007.01088.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,28]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1111\/j.1600-0420.2007.01088.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0420.2007.01088.x","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,28]]},"assertion":[{"value":"2008-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}