{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:50:04Z","timestamp":1757573404320},"reference-count":7,"publisher":"Wiley","issue":"S291","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":9610,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>Most extrapyramidal side effects of neuroleptics are easily recognized and cause little problem in diagnosis and treatment. The exceptions are those which mimic psychopathology: akathesia and akinisia. Akathesia resembles anxiety. Akinesia is similar to depression, residual schizophrenia, and demoralization. Differential diagnosis may require interruption of the neuroleptic. Whether neuroleptics can cause depression not associated with akinesia has never been established. The first obligation of the clinician is to be sure that the depressive symptoms are not concomitants of akinesia, before treating with antidepressants which may not be the appropriate treatment. There is no convincing evidence that one neuroleptic drug is more likely to cause akinesia than another, although this had not been studied extensively using a broad definition of akinesia.<\/jats:p>","DOI":"10.1111\/j.1600-0447.1981.tb02465.x","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T09:49:51Z","timestamp":1187862591000},"page":"129-136","source":"Crossref","is-referenced-by-count":12,"title":["The risks of long\u2010term neuroleptic treatment of schizophrenia: especially depression and akinesia"],"prefix":"10.1111","volume":"63","author":[{"given":"A.","family":"Rifkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.131.1.86"},{"key":"e_1_2_1_3_1","volume-title":"Diagnosis and drug treatment of psychiatric illness","author":"Klein D. F.","year":"1980"},{"key":"e_1_2_1_4_1","unstructured":"Meyer J. E. &P.Muller(1979):Presented at the International Workshop on the efficacy and risk of preventing relapse in schizophrenia with neuroleptics. G\u00f6ttingen February."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1977.01770130045004"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770280093010"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1970.tb02066.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310095007"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.1981.tb02465.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.1981.tb02465.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:23:02Z","timestamp":1699460582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.1981.tb02465.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5]]},"references-count":7,"journal-issue":{"issue":"S291","published-print":{"date-parts":[[1981,5]]}},"alternative-id":["10.1111\/j.1600-0447.1981.tb02465.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.1981.tb02465.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,5]]}}}