{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:21:43Z","timestamp":1774282903583,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":6900,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A cohort of manic\u2010depressive patients given prophylactic lithium treatment were examined before treatment started and at intervals during treatment for up to 7 years. The mean lithium dosage was 23.2 mmol\/d and the mean serum lithium concentration 0.68 mmol\/1. About 40% of the patients were entirely free of side effects, as compared with 10% among patients treated previously with higher lithium doses and serum lithium concentrations. Tremor complaints were presented by 5% of the patients before and by 15% during lithium treatment. The frequency fell with continued treatment, and after a few years it was not higher than before treatment started. Tremor complaints were positively correlated with age and with the use of neuroleptics and antidepressants. The tremorigenic effects of lithium and antidepressants seemed to potentiate each other. Tremor complaints were more frequent at serum lithium levels over than under 0.7 mmol\/1. Body weight increased during the first 1\u20132 years of lithium treatment and then remained constant. The average gain was 4 kg. Weight gain was positively correlated with the patients\u2019 body weight before treatment and with the concurrent administration of antidepressant drugs. The frequency of diarrhea complaints (loose stools, defecation urge) rose from 1% to 6% during the first 6 months of lithium treatment and then leveled off. The frequency rose steeply at serum lithium values over 0.8 mmol\/1.<\/jats:p><jats:p>During lithium administration about one tenth of the patients had psychological complaints, which might or might not have been caused by the treatment: memory impairment and concentrating difficulty, tiredness and \u201cgreyness of life\u201d, in a few cases altered taste or lowered libido and potency.<\/jats:p>","DOI":"10.1111\/j.1600-0447.1988.tb06363.x","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T11:00:27Z","timestamp":1187866827000},"page":"434-441","source":"Crossref","is-referenced-by-count":101,"title":["Prospective studies on a lithium cohort"],"prefix":"10.1111","volume":"78","author":[{"given":"P.","family":"Vestergaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Poulstrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1988.tb06361.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1987.tb02778.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1980.tb00607.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1977.tb00163.x"},{"key":"e_1_2_1_6_2","first-page":"578","article-title":"Lithium salts: Therapeutic and unwanted effects","volume":"18","author":"Ghose K.","year":"1981","journal-title":"Br J Hosp Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000117678"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.5.482"},{"key":"e_1_2_1_9_2","first-page":"103","article-title":"Incidence of side effects in patients on long\u2010term lithium therapy","volume":"137","author":"Bone S.","year":"1981","journal-title":"Am J Psychiatry"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1017237"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700050066"},{"key":"e_1_2_1_12_2","first-page":"839","article-title":"Propranolol and lithium\u2010induced tremor","author":"Kirk L.","year":"1981","journal-title":"Lancet"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1977.tb00152.x"},{"key":"e_1_2_1_14_2","first-page":"376","article-title":"Vergleich von Lithium\u2010Nebenwirkungen zwischen einem Kurzzeit\u2010(Quilonum) und einem Depotpr\u00e4parat (Lithium Duriles)","volume":"42","author":"Matussek N.","year":"1981","journal-title":"Nervenarzt"},{"key":"e_1_2_1_15_2","unstructured":"RybakowskiJ. Clopocka\u2010WozniakM. RajewskaJ..Objawy uboczne w czasie dlugotrwalego stosowania litu w celach profilaktyki chorob afektywnych. Proc Pol Psychiatr Assoc Meeting Gdansk 1983:203\u2013211."},{"key":"e_1_2_1_16_2","first-page":"335","volume-title":"Psycho\u2010pharmacology, sexual disorders and drug abuse","author":"Kanowski S.","year":"1973"},{"key":"e_1_2_1_17_2","first-page":"294","article-title":"Lithium salts","volume":"19","author":"Loudon J B","year":"1981","journal-title":"Br J Hosp Med"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-7197-7_7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-6080(83)80007-5"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.116.535.615"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1970.tb02116.x"},{"key":"e_1_2_1_22_2","first-page":"323","volume-title":"Psychopharmacology, sexual disorders and drug abuse","author":"Grof P.","year":"1973"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1976.tb00067.x"},{"key":"e_1_2_1_24_2","first-page":"5","article-title":"Variacao de peso causada pelo uso cronico do litio","volume":"34","author":"Teixeira N A","year":"1981","journal-title":"J Bras Psiquiatr"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1988.tb06362.x"},{"key":"e_1_2_1_26_2","first-page":"88","article-title":"Lithium and insulin: Effects on carbohydrate and electrolyte metabolism","volume":"21","author":"Mellerup E T","year":"1981","journal-title":"Dan Med Bull"},{"key":"e_1_2_1_27_2","first-page":"69","article-title":"Pharmakokinetik und Toxikologie des Lithiums","volume":"161","author":"Greil W.","year":"1981","journal-title":"Bibliotheca Psychiatr"},{"key":"e_1_2_1_28_2","unstructured":"SchouM. AmdisenA. ThomsenK..The effect of lithium on the normal mind. In:Baudi\u0161P. Peterov\u00e1E. \u0160edivecV. eds.De psychiatria progrediente. Plzen 1968:712\u2013721."}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.1988.tb06363.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.1988.tb06363.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:17:39Z","timestamp":1697890659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.1988.tb06363.x"}},"subtitle":["3. Tremor, weight gain, diarrhea, psychological complaints"],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1111\/j.1600-0447.1988.tb06363.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.1988.tb06363.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}