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A small amplitude of the event\u2010related P3 (P300) potential could be a marker of this subgroup, because the cortical neurons and their orderly laminar arrangement are crucial for the electrogenesis of P3. In a 2\u2010year follow\u2010up study, auditory evoked P3 was recorded in 89 stabilized schizophrenic outpatients. Patients who developed tardive dyskinesia during the follow\u2010up had smaller P3 than matched controls. Furthermore, a small P3 was associated with low premorbid adjustment, pronounced residual symptoms, low relapse rate, and male predominance. These findings indicate that schizophrenic patients with a reduced P3 have a higher risk of developing tardive dyskinesia and correspond clinically to a schizophrenic subgroup with a supposedly neurodevelopmental disturbance.<\/jats:p>","DOI":"10.1111\/j.1600-0447.1995.tb09751.x","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T13:21:52Z","timestamp":1187875312000},"page":"120-125","source":"Crossref","is-referenced-by-count":56,"title":["Schizophrenics with small P300: a subgroup with a neurodevelopmental disturbance and a high risk for tardive 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