{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:29:23Z","timestamp":1790742563283,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"S403","license":[{"start":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T00:00:00Z","timestamp":1185494400000},"content-version":"vor","delay-in-days":2520,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>Peretti S, Judge R, Hindmarch I. Safety and tolerability considerations: tricyclic antidepressants vs. selective serotonin reuptake inhibitors. Acta Psychiatr Scand 2000: 101: 17\u201325. \u00a9 Munksgaard 2000.<\/jats:p><jats:p>Objective: An important consideration in the choice of an antidepressant is its safety and tolerability.<\/jats:p><jats:p>Method: We present a review of literature, clinical trials and meta\u2010analyses regarding the safety and tolerability of the tricyclic antidepressants (TCAs) and the selective serotonin reuptake inhibitors (SSRIs) in depressed patients.<\/jats:p><jats:p>Results: The SSRIs have a very favourable side\u2010effect profile compared to the TCAs and are associated with fewer treatment discontinuations. Unlike the TCAs, they do not cause anticholinergic, hypotensive or sedating reactions, and are not associated with impaired cognitive function. Their most common side\u2010effects (nausea, vomiting, nervousness, insomnia, headache and sexual dysfunction) are usually mild and typically disappear as treatment continues. The SSRTs also exhibit lower toxicity and lower lethality when taken in an overdose situation. Although the safety profiles of the principal SSRTs appear to be comparable, there is some data showing important differences in the severity and frequency of specific adverse events.<\/jats:p><jats:p>Conclusion: The SSRTs have a more favourable safety profile than the TCAs in both acute and long\u2010term treatment of major depression.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2000.tb10944.x","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T13:28:56Z","timestamp":1185542936000},"page":"17-25","source":"Crossref","is-referenced-by-count":187,"title":["Safety and tolerability considerations: tricyclic antidepressants vs. selective serotonin reuptake 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