{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:57:41Z","timestamp":1765666661334},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T00:00:00Z","timestamp":1100044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate the association between duration of untreated psychosis (DUP) and treatment outcome in a sample of subjects from a developing country.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Forty\u2010eight subjects with a first episode of psychosis were evaluated prior to treatment and at 3\u2010month intervals over a period of 24\u2003months. We first examined correlations between DUP and symptom improvement as measured on the Positive and Negative Symptom Scale (PANSS), and then performed multivariate analysis to determine the validity of DUP as a predictor of outcome.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> DUP was significantly correlated with improvement in PANSS total and negative subscale scores as well as the PANSS depression factor at 21 and 24\u2003months. Multivariate analysis found DUP to be the only significant predictor of improvement in negative symptoms at 24\u2003months.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> DUP was a significant predictor of outcome in a cohort form a developing country. 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