{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:16:15Z","timestamp":1759032975763},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To examine the risk of relapse into mania or depression with varying duration of antidepressant treatment in a cohort of 59 patients with bipolar disorder.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> An open naturalistic evaluation using life charting methods of patients with 1\u2003year follow\u2010up, who responded to antidepressant treatment and who then less or more than 6\u2003months of antidepressant treatment.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Patients who received more than 6\u2003months of antidepressant treatment were less likely to relapse into depression at follow\u2010up of 1\u2003year. There was no difference in relapse rates for mania in the different antidepressant treatment duration groups. Gender and bipolar subtype did not significantly affect relapse rates for depression or mania.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our data, taken with other studies, suggest that the duration of optimal antidepressant treatment in bipolar disorder must be further evaluated.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2005.00583.x","type":"journal-article","created":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T17:35:22Z","timestamp":1120239322000},"page":"105-109","source":"Crossref","is-referenced-by-count":39,"title":["One\u2010year outcome with antidepressant \u2013 treatment of bipolar depression"],"prefix":"10.1111","volume":"112","author":[{"given":"R. T.","family":"Joffe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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