{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:18:44Z","timestamp":1791998324439,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T00:00:00Z","timestamp":1128556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global <jats:italic>P<\/jats:italic>\u2010value\u2003&gt;\u20030.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over\u2010transmitted to persons with a history of manic psychosis.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results suggest that the <jats:italic>neuregulin 1<\/jats:italic> gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2005.00631.x","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T11:38:19Z","timestamp":1128598699000},"page":"314-321","source":"Crossref","is-referenced-by-count":32,"title":["Association analyses of the <i>neuregulin 1<\/i> gene with schizophrenia and manic psychosis in a Hispanic population"],"prefix":"10.1111","volume":"113","author":[{"given":"C.","family":"Walss\u2010Bass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Raventos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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