{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:25:27Z","timestamp":1759483527903},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T00:00:00Z","timestamp":1142294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> In this prospective study, temperament and character were evaluated in patients with panic disorder (PD), before 1\u2003year of medication therapy, to verify whether these factors influenced the outcome of treatment.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Seventy\u2010one PD patients were evaluated with the SCID\u2010IV, the Temperament and Character Inventory (TCI), the SCL\u201090, the Ham\u2010A and the Ham\u2010D. Patients were treated with pharmacotherapy and were evaluated monthly over 1\u2003year.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Before treatment, non\u2010remitted patients showed higher levels of harm avoidance (HA) and lower levels of persistence (P), self\u2010directedness (SD) and cooperativeness (C), whereas remitted patients showed only higher levels of HA. After controlling the effect of the confounding variables, the likelihood to achieve remission was positively related to SD score (OR\u2003=\u20031.12; <jats:italic>P<\/jats:italic>\u2003=\u20030.002), particularly \u2018self\u2010acceptance\u2019 SD dimension (OR\u2003=\u20031.30; <jats:italic>P<\/jats:italic>\u2003=\u20030.02).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our data suggest that in PD: i) the evaluation of personality, using the Cloninger's model, confirms the presence of personality pathology as one predictor of non\u2010response to treatment; ii) in patients with low SD a combination of medication and cognitive\u2010behaviour therapy should be the most effective treatment.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2006.00772.x","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T15:25:47Z","timestamp":1142349947000},"page":"203-210","source":"Crossref","is-referenced-by-count":18,"title":["The effect of temperament and character on response to selective serotonin reuptake inhibitors in panic disorder"],"prefix":"10.1111","volume":"114","author":[{"given":"C.","family":"Marchesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Font\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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