{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:06:00Z","timestamp":1770969960470,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T00:00:00Z","timestamp":1151280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold>This study sought to examine the effectiveness of sibutramine, a weight loss agent, on clozapine\u2010associated weight gain.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold>This was a 12\u2010week double\u2010blind, placebo controlled, randomized trial of sibutramine for weight loss in obese clozapine\u2010treated schizophrenia or schizoaffective disorder subjects.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Ten patients were enrolled into the placebo group and 11 patients into the sibutramine group. There were no significant baseline differences between the two groups on age, gender, education, ethnicity, diagnosis, weight, body mass index (BMI), and blood pressure. At week 12, there were no significant differences in changes in weight, BMI, abdominal and waist circumferences, Hba1c, fasting glucose, or cholesterol levels.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>Sibutramine treatment did not show significant weight loss compared with placebo in clozapine\u2010treated patients with schizophrenia or schizoaffective disorder. Further research with a larger sample size and longer follow\u2010up duration is warranted.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2006.00855.x","type":"journal-article","created":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T12:08:10Z","timestamp":1151323690000},"page":"101-105","source":"Crossref","is-referenced-by-count":48,"title":["A double\u2010blind, placebo\u2010controlled trial of sibutramine for clozapine\u2010associated weight gain"],"prefix":"10.1111","volume":"115","author":[{"given":"D. C.","family":"Henderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Borba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. B.","family":"Daley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Freudenreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cather","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Evins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Goff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,26]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.6.975"},{"issue":"27","key":"e_1_2_9_4_2","first-page":"10","article-title":"Clinical experience with insulin resistance, diabetic ketoacidosis, and type 2 diabetes mellitus in patients treated with atypical antipsychotic agents","volume":"62","author":"Henderson DC","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2004.00451.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2004.00372.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1381\/096089202762552601"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2003.00218.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00612.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.15.1814"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011620"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.144"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.954"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820080032005"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(94)00129-N"},{"key":"e_1_2_9_16_2","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0022-3565(24)37732-8","article-title":"S 16924 ((R)\u20102\u2010[1\u2010[2\u2010(2,3\u2010dihydro\u2010benzo[1,4] dioxin\u20105\u2010yloxy)\u2010ethyl]\u2010pyrrolidin\u20103yl]\u20101\u2010(4\u2010fluoro\u2010phenyl)\u2010ethanone), a novel, potential antipsychotic with marked serotonin (5\u2010HT)1A agonist properties: II. Functional profile in comparison to clozapine and haloperidol","volume":"286","author":"Millan MJ","year":"1998","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2006.00855.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2006.00855.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:28:27Z","timestamp":1736436507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2006.00855.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,26]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1600-0447.2006.00855.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2006.00855.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,26]]}}}