{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:08:22Z","timestamp":1782248902461,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T00:00:00Z","timestamp":1170892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To compare the efficacy and tolerability of tranylcypromine vs. lamotrigine in bipolar depression not responding to conventional antidepressants.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Bipolar depressed patients received open randomized treatment with tranylcypromine or lamotrigine as add\u2010on to a mood stabilizer during 10\u2003weeks. In a second treatment phase, non\u2010responding patients could receive the opposite drug. Outcome criteria were response (measured with CGI\u2010BP and IDS\u2010C), switch into mania, and completion of the study.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Only 20 of 70 planned patients were randomized, due to problems with recruitment, and 19 patients received any medication. During the first treatment phase 5\/8 patients (62.5%) responded to tranylcypromine without switch into mania, compared with 4\/11 patients (36.4%) on lamotrigine with two switches (statistically not significant). Over both treatment phases, 8\/10 patients (80%) receiving tranylcypromine completed the study vs. 5\/13 (38.5%) on lamotrigine (likelihood 0.02).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> There still appears to be a role for tranylcypromine in the treatment of refractory bipolar depression. Larger controlled studies are demanded.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2007.00993.x","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T11:21:10Z","timestamp":1170933670000},"page":"360-365","source":"Crossref","is-referenced-by-count":44,"title":["Tranylcypromine vs. lamotrigine in the treatment of refractory bipolar depression: a failed but clinically useful study"],"prefix":"10.1111","volume":"115","author":[{"given":"W. A.","family":"Nolen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Kupka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hellemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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