{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:21:29Z","timestamp":1789924889867,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T00:00:00Z","timestamp":1195084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Consensus operational definitions for symptomatic remission and recovery of a major depressive episode have been proposed but only irregularly followed.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> We examined the predictive validity of different definitions of recovery in a multi\u2010center 10\u2010year follow\u2010up study of an inception cohort of untreated unipolar major depressive episodes (<jats:italic>n<\/jats:italic>\u2003=\u200395). Time to recovery and time to recurrence after recovery were estimated by Kaplan\u2013Meier survival analyses for alternative definitions requiring 2, 4, 6 or 12\u2003months of remission to declare recovery.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The median time to recovery was 3.0, 4.0, 4.0 and 12.0\u2003months respectively. The index episode lasted longer than 24\u2003months in 9.4%, 9.2%, 12.6% and 24.5%. The median time to subthreshold recurrence was 16.0, 32.0, 42.0 and 74.0\u2003months.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Either 4\u2010 or 6\u2010month duration of remission defined a change point before which the episode was continuous and after which the recurrence was reasonably unlikely.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2007.01119.x","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T09:03:01Z","timestamp":1194426181000},"page":"35-40","source":"Crossref","is-referenced-by-count":28,"title":["Definitions of recovery and outcomes of major depression: results from a 10\u2010year follow\u2010up"],"prefix":"10.1111","volume":"117","author":[{"given":"T. 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