{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:11:19Z","timestamp":1785298279335,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T00:00:00Z","timestamp":1201651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> P50 gating in schizophrenia has contributed much to our understanding of the pathophysiology of the illness. We examined euthymic bipolar patients to determine if they also have a P50 gating deficit.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> P50 gating was measured in 81 euthymic bipolar patients (50 with a lifetime history of psychotic symptoms), 92 stable schizophrenic patients, and 67 control subjects.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> P50 gating was significantly lower in control subjects than in bipolar patients with a lifetime history of psychosis (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) and schizophrenic patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.0001). In all patient groups, the percentage of patients with P50 gating was higher than in the control group (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u200330.596; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). There was no statistically significant correlation between P50 gating and other clinical variables.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our data suggest that P50 gating deficit is a neurobiological marker that is present in stable schizophrenic patients and euthymic bipolar patients.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2007.01141.x","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T15:01:11Z","timestamp":1201705271000},"page":"313-318","source":"Crossref","is-referenced-by-count":83,"title":["P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia"],"prefix":"10.1111","volume":"117","author":[{"given":"E. M.","family":"S\u00e1nchez\u2010Morla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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