{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:55:02Z","timestamp":1789836902889,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T00:00:00Z","timestamp":1203984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    To establish whether the combination of cognitive\u2010behavioral therapy (CBT) and pharmacotherapy (SSRI) was more effective in treating panic disorder (PD) than either CBT or SSRI alone, and to evaluate any differential effects between the mono\u2010treatments.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method:\u2002<\/jats:bold>\n                    Patients with PD (\n                    <jats:italic>n\u2003<\/jats:italic>\n                    =\n                    <jats:italic>\u2003<\/jats:italic>\n                    150) with or without agoraphobia received CBT, SSRI or CBT\u2003+\u2003SSRI. Outcome was assessed after 9\u2003months, before medication taper.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    CBT\u2003+\u2003SSRI was clearly superior to CBT in both completer and intent\u2010to\u2010treat analysis (ITT). Completer analysis revealed superiority of CBT\u2003+\u2003SSRI over SSRI on three measures and no differences between CBT and SSRI. ITT analysis revealed superiority of SSRI over CBT on four measures and no differences between CBT\u2003+\u2003SSRI and SSRI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Both the mono\u2010treatments (CBT and SSRI) and the combined treatment (CBT\u2003+\u2003SSRI) proved to be effective treatments for PD. At post\u2010test, CBT\u2003+\u2003SSRI was clearly superior to CBT, but differences between CBT\u2003+\u2003SSRI and SSRI, and between SSRI and CBT, were small.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0447.2008.01157.x","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T22:00:03Z","timestamp":1204063203000},"page":"260-270","source":"Crossref","is-referenced-by-count":47,"title":["Is a combined therapy more effective than either CBT or SSRI alone? Results of a multicenter trial on panic disorder with or without agoraphobia"],"prefix":"10.1111","volume":"117","author":[{"given":"F. J.","family":"Van Apeldoorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J. P. J.","family":"Van Hout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. P. A.","family":"Mersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. R.","family":"Slaap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"W. W.","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Van Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Den Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,26]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.4.415"},{"issue":"8","key":"e_1_2_8_3_2","first-page":"47","article-title":"Consensus statement on panic disorder from the international consensus group on depression and anxiety","volume":"59","author":"Ballenger JC","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2005.07.003"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470854871.chxix13"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1017\/S1092852900018617","article-title":"Cognitive\u2010behavioral therapy for panic disorder: a review of treatment elements, strategies, and outcomes","volume":"8","author":"Recker Rayburn N","year":"2003","journal-title":"CNS Spectr"},{"issue":"2","key":"e_1_2_8_7_2","first-page":"A87","article-title":"An integrated treatment approach to panic disorder","volume":"60","author":"Craske MG","year":"1996","journal-title":"Bull Menninger Clin"},{"issue":"5","key":"e_1_2_8_8_2","first-page":"34","article-title":"Cognitive\u2010behavioral therapy for the treatment of anxiety disorders","volume":"65","author":"Otto MW","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.19.2529"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.5.683"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(92)90094-M"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb09636.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/070674379504000406","article-title":"Clomipramine treatment and behaviour therapy with agoraphobic women","volume":"40","author":"Johnston DG","year":"1995","journal-title":"Can J Psychiatry"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790020047004"},{"key":"e_1_2_8_15_2","first-page":"117","article-title":"Agoraphobia: relative and combined effectiveness of therapist\u2010assisted in vivo exposure and imipramine","volume":"47","author":"Mavissakalian M","year":"1986","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.167.3.374"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-6185(96)00008-4"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90011-7"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n1205"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820130046008"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.6.759"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(94)90008-6"},{"issue":"20","key":"e_1_2_8_23_2","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheenan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(86)90011-2"},{"key":"e_1_2_8_25_2","volume-title":"Clinical handbook of psychological disorders","author":"Craske MG","year":"1993"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(97)10016-X"},{"key":"e_1_2_8_27_2","unstructured":"Van BalkomAJLM Van DyckR Van MegenHJGM TimmermanL Van VlietIM WestenbergHGM WitteYC eds.Richtlijn farmacotherapie angststoornissen. Amsterdam:Dries van Ingen Uitgeverij Boom 1998:7\u201337."},{"key":"e_1_2_8_28_2","first-page":"217","volume-title":"ECDUE assessment manual for psychopharmacology","author":"National Institute of Mental Health","year":"1976"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(79)90041-X"},{"key":"e_1_2_8_32_2","volume-title":"SCL\u201090: handleiding bij een multidimensionele psychopathologie\u2010indicator","author":"Arrindel WA","year":"2003"},{"key":"e_1_2_8_33_2","first-page":"13","article-title":"SCL\u201090: an outpatient psychiatric rating scale \u2013 preliminary report","volume":"9","author":"Derogatis LR","year":"1973","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.2307\/2685779"},{"key":"e_1_2_8_35_2","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm S","year":"1979","journal-title":"Scand J Stat"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2000.tb10947.x"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/026988119601000314"},{"issue":"4","key":"e_1_2_8_39_2","first-page":"23","article-title":"The pharmacotherapy of panic disorder","volume":"66","author":"Pollack MH","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/clipsy.bpi009"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2008.01157.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2008.01157.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:47:36Z","timestamp":1696974456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2008.01157.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,26]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1600-0447.2008.01157.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2008.01157.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1116485.572511","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1116485.573982","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,26]]}}}