{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T06:42:34Z","timestamp":1697524954553},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T00:00:00Z","timestamp":1206921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> The aim of the study was to analyze treatments and outcome in depressed patients.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Patients with recurrent depressive disorder (<jats:italic>n<\/jats:italic>\u2003=\u2003289), recruited for a prophylaxis study, were followed up in hospital settings for 6\u2003months with diagnostic and depression ratings at baseline and monthly depression ratings. Data on psychotropic drugs were retrieved from hospital case records. Independent associations between baseline, treatment and outcome variables were examined by logistic regression models.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Depressive symptoms subsided gradually. After 6\u2003months, 21% had dropped out, 43% were rated as remitted (HAM\u2010D\u201017 &lt;8) and 8% had not responded (HAM\u2010D\u201017 &gt;15). Patients once remitted rarely relapsed (&lt;5%). All patients received antidepressant drugs, half of them more than one (2\u20134) as well as other psychotropic drugs. Patients responding poorly received more frequently multiple antidepressants, tricyclic antidepressants, hypnosedatives, lithium and\/or antipsychotics.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The 6\u2010month outcome was generally poor. Choice of treatment appeared at least partly to be determined by the therapeutic outcome.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2008.01182.x","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T09:29:43Z","timestamp":1206955783000},"page":"123-129","source":"Crossref","is-referenced-by-count":3,"title":["Acute and continuation therapy in unipolar depression: observations from the run\u2010in phase of a maintenance trial"],"prefix":"10.1111","volume":"118","author":[{"name":"Danish University Antidepressant Group (DUAG)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,10]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7116.1143"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/57.1.145"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10673229809003578"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12599-8"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n1002"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700033146"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000012261"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(98)00004-2"},{"key":"e_1_2_9_10_2","article-title":"Dysthymia in clinical practice","volume":"89","author":"Costa e Silva JA","year":"1994","journal-title":"Acta Psychiatr Scand"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.4.438"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.10180"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422010"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.NMD.0000061144.16176.38"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802605774297092"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0915"},{"key":"e_1_2_9_17_2","first-page":"131","article-title":"Citalopram; clinical effect profile in comparison with clomipramine. \u2013 a controlled multicenter study","volume":"90","author":"Danish University Antidepressant Group","year":"1986","journal-title":"Psychopharmacology"},{"key":"e_1_2_9_18_2","first-page":"289","article-title":"Paroxetine; a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine \u2013 a controlled multicenter study","volume":"18","author":"Danish University Antidepressant Group","year":"1993","journal-title":"J Affect Disord"},{"key":"e_1_2_9_19_2","volume-title":"SCAN \u2013 schedules for clinical assessment in neuropsychiatry","author":"WHO","year":"1994"},{"key":"e_1_2_9_20_2","volume-title":"The ICD\u201010 classification of mental and behavioral disorders \u2013 diagnostic criteria for research","author":"WHO"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"issue":"326","key":"e_1_2_9_22_2","first-page":"1","article-title":"Mini\u2010compendium","volume":"73","author":"Bech P","year":"1986","journal-title":"Acta Psychiatr Scand"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1975.tb00002.x"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.111.477.659"},{"key":"e_1_2_9_25_2","volume-title":"Diagnostic scales for affective disorder","author":"Gurney C","year":"1971"},{"key":"e_1_2_9_26_2","doi-asserted-by":"crossref","volume-title":"Rating scales for psychopathology, health status and quality of life","author":"Bech P","DOI":"10.1007\/978-3-642-77759-2"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411173312008"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/cp.1999.v66.99720"},{"key":"e_1_2_9_29_2","volume-title":"Non parametric statistics for the behavioral sciences","author":"Siegel S","year":"1988"},{"key":"e_1_2_9_30_2","volume-title":"MedStat statistical program","author":"Wulff HR"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"e_1_2_9_32_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1176\/ajp.2007.164.2.201","article-title":"STAR*D: What have we learned?","volume":"164","author":"Rush AJ","year":"2007","journal-title":"Am J Psychiatry"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.010470"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/9780203007051"},{"key":"e_1_2_9_35_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00228-003-0593-3","article-title":"Antidepressant drug use in general practice: Inter\u2010practice variation and association with practice characteristics","volume":"59","author":"Hansen DG","year":"2003","journal-title":"Eur J Clin Pharmacol"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/026988110001400101"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2008.01182.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2008.01182.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:38:22Z","timestamp":1697431102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2008.01182.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1111\/j.1600-0447.2008.01182.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2008.01182.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,10]]}}}