{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:28:09Z","timestamp":1790418489405,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,4,13]],"date-time":"2008-04-13T00:00:00Z","timestamp":1208044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Gender differences exist in the prevalence and psychiatric comorbidity of major depressive disorder (MDD). This study investigates whether familiality of MDD contributes to observed gender differences in comorbidity.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Familial (f\u2010MDD) and non\u2010familial (nf\u2010MDD) MDD cases from a population sample were assessed for comorbid dysthymia, anxiety disorders and alcohol\u2010related disorders using the Composite International Diagnostic Interview (CIDI). Logistic regression analyses were performed to examine the effect of f\u2010MDD on gender differences in comorbidity, adjusted for confounders.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Women with f\u2010MDD reported significantly more comorbid dysthymia and generalized anxiety disorder (GAD) than their male counterparts; women with nf\u2010MDD reported significantly more comorbid simple phobias and agoraphobia than their male counterparts. Gender differences in comorbid panic disorder and alcohol\u2010related disorders occurred independently of the familial load. Adjustment for age of onset, severity and recurrence of MDD did not change these results.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Models to explain comorbidity patterns of MDD differ by gender. Familiality of MDD should be taken into account.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2008.01186.x","type":"journal-article","created":{"date-parts":[[2008,4,14]],"date-time":"2008-04-14T01:56:58Z","timestamp":1208138218000},"page":"130-138","source":"Crossref","is-referenced-by-count":11,"title":["Familiality of major depressive disorder and gender differences in comorbidity"],"prefix":"10.1111","volume":"118","author":[{"given":"M.","family":"Verhagen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Van Der Meij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Franke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Vollebergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"De Graaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Buitelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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