{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:13:46Z","timestamp":1790270026446,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T00:00:00Z","timestamp":1221782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    Evidence based on controlled studies is still limited for treatment strategies that prevent recurrence of suicide attempts. Findings from observational as well as meta\u2010analytic studies strongly suggest that lithium may have suicide\u2010protective properties.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method:\u2002<\/jats:bold>\n                    Patients with a recent suicide attempt in the context of an affective spectrum disorder (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u2003167) were treated with either lithium or placebo during a 12\u2010month period.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Survival analysis showed no significant difference of suicidal acts between lithium and placebo\u2010treated individuals (adjusted hazard ratio 0.517; 95% CI 0.18\u20131.43). However,\n                    <jats:italic>post hoc<\/jats:italic>\n                    analysis revealed that all completed suicides had occurred in the placebo group accounting for a significant difference in incidence rates (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\n                    <jats:italic>\u2003<\/jats:italic>\n                    0.049).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Results indicate that lithium treatment might be effective in reducing the risk of completed suicide in adult patients with affective disorders. Our findings contribute to the growing body of evidence suggesting a specific antisuicidal effect of lithium.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0447.2008.01266.x","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T19:53:35Z","timestamp":1221854015000},"page":"469-479","source":"Crossref","is-referenced-by-count":125,"title":["Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: a randomised, placebo\u2010controlled, 1\u2010year 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