{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T21:12:10Z","timestamp":1794517930917,"version":"4.9.1"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T00:00:00Z","timestamp":1235001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold>To quantify the risk of developing dementia in those with mild cognitive impairment (MCI).<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold>Meta\u2010analysis of inception cohort studies.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Forty\u2010one robust cohort studies were identified. To avoid heterogeneity clinical studies, population studies and clinical trials were analysed separately. Using Mayo defined MCI at baseline and adjusting for sample size, the cumulative proportion who progressed to dementia, to Alzheimer\u2019s disease (AD) and to vascular dementia (VaD) was 39.2%, 33.6% and 6.2%, respectively in specialist settings and 21.9%, 28.9% and 5.2%, respectively in population studies. The adjusted annual conversion rate (ACR) from Mayo defined MCI to dementia, AD and VaD was 9.6%, 8.1% and 1.9%, respectively in specialist clinical settings and 4.9%, 6.8% and 1.6% in community studies. Figures from non\u2010Mayo defined MCI and clinical trials are also reported.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>The ACR is approximately 5\u201310% and most people with MCI will not progress to dementia even after 10\u2003years of follow\u2010up.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2008.01326.x","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T10:24:54Z","timestamp":1235039094000},"page":"252-265","source":"Crossref","is-referenced-by-count":1398,"title":["Rate of progression of mild cognitive impairment to dementia \u2013 meta\u2010analysis of 41 robust inception cohort studies"],"prefix":"10.1111","volume":"119","author":[{"given":"A. 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