{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:38:14Z","timestamp":1775075894982,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T00:00:00Z","timestamp":1243555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> We aimed to quantify both load and regional distributions of hyperintensities on magnetic resonance imaging (MRI) in prospectively verified euthymic bipolar patients and matched controls.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Cerebral hyperintensities on T2, proton density and fluid\u2010attenuated inversion recovery (FLAIR) MRI were compared between 48 bipolar and 47 control subjects using semi\u2010quantitative rating scales.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Bipolar subjects had more severe frontal deep white matter lesions (DWML). Hyperintensity load was independent of age in bipolar patients but increased with age in controls. Global prevalence and severity of hyperintensities did not differ between groups. Exploratory analysis showed DWML in excess in the left hemisphere in bipolar subjects but not in controls.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Findings are consistent with clinical, particularly some neurocognitive, features of bipolar disorder and implicate fronto\u2010subcortical circuits in its neurobiology. They more probably reflect a trait abnormality or illness scar rather than a mood state\u2010dependent finding. Processes other than ageing and vascular factors may underlie their development.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2009.01416.x","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T04:02:09Z","timestamp":1243569729000},"page":"481-491","source":"Crossref","is-referenced-by-count":21,"title":["White matter lesions in euthymic patients with bipolar disorder"],"prefix":"10.1111","volume":"120","author":[{"given":"A. J.","family":"Lloyd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. B.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Cousins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. L.","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. N.","family":"Ferrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,10]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.9.1017"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00006-6"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418519403500203"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.9"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.7.1171"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000368814"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91144-B"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1795"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051184"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb10146.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199608)11:8<681::AID-GPS426>3.0.CO;2-U"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000117275"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00100-U"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810130057008"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.3.1.18"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.8.1139"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810230070011"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00341-2"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00363-0"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.5.687"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199203000-00012"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199506000-00014"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(01)00129-9"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.5.620"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2000.101004274.x"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(97)00060-1"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00170-2"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90140-9"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00626.x"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.2.172"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950210041009"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.9.1521"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-007-0755-x"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1090"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1683"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530150061019"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.04.009"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.157.1.50"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.1.41"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.186.1.32"},{"key":"e_1_2_9_42_2","first-page":"1","article-title":"Neurocognitive functions in euthymic bipolar patients","volume":"119","author":"Jamrozinski K","year":"2008","journal-title":"Acta Psychiatr Scand"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540080076020"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900020800"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(75)80005-0"},{"key":"e_1_2_9_46_2","volume-title":"Standard occupational classification","author":"OPCS","year":"1991"},{"key":"e_1_2_9_47_2","volume-title":"National adult reading test","author":"Nelson HE","year":"1982"},{"key":"e_1_2_9_48_2","volume-title":"Structured clinical interview for DSM\u2010IV axis I disorders, research version","author":"First MB","year":"1997"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00548-3"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_54_2","volume-title":"AUDIT: The alcohol use disorders identification test: Guidelines for use in primary health care","author":"Babor TF","year":"1992"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90041-V"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000049766.26453.E9"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.6.488"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144280.59178.78"},{"key":"e_1_2_9_60_2","volume-title":"Co\u2010planar stereotaxic atlas of the human brain","author":"Talairach J","year":"1988"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00084-5"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.011098"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.9.785"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00610-3"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-007-9035-9"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf149"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14289-4"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.12.019"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.06.021"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.504"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2009.01416.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2009.01416.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:44:34Z","timestamp":1697409874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2009.01416.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,10]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1111\/j.1600-0447.2009.01416.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2009.01416.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,10]]}}}