{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:43:14Z","timestamp":1791934994142,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>Tondo L, Lepri B, Cruz N, Baldessarini RJ. Age at onset in 3014 Sardinian bipolar and major depressive disorder patients.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To test if onset age in major affective illnesses is younger in bipolar disorder (BPD) than unipolar\u2010major depressive disorder (UP\u2010MDD), and is a useful measure.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> We evaluated onset\u2010age for DSM\u2010IV\u2010TR major illnesses in 3014 adults (18.5% BP\u2010I, 12.5% BP\u2010II, 69.0% UP\u2010MDD; 64% women) at a mood\u2010disorders center.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Median and interquartile range (IQR) onset\u2010age ranked: BP\u2010I\u2003=\u200324 (19\u201332)\u2003&lt;\u2003BP\u2010II\u2003=\u200329 (20\u201340)\u2003&lt;\u2003UP\u2010MDD\u2003=\u200332 (23\u201347) years (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), and has remained stable since the 1970s. In BP\u2010I patients, onset was latest for hypomania, and depression presented earlier than in BP\u2010II or UP\u2010MDD cases. Factors associated with younger onset included: i) being unmarried, ii) more education, iii) BPD\u2010diagnosis, iv) family\u2010history, v) being employed, vi) ever\u2010suicidal, vii) substance\u2010abuse and viii) ever\u2010hospitalized. Onset\u2010age distinguished BP\u2010I from UP\u2010MDD depressive onsets with weak sensitivity and specificity.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Onset age was younger among BPD than MDD patients, and very early onset may distinguish BPD vs. UP\u2010MDD with depressive\u2010onset.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2009.01523.x","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T07:18:05Z","timestamp":1261552685000},"page":"446-452","source":"Crossref","is-referenced-by-count":54,"title":["Age at onset in 3014 Sardinian bipolar and major depressive disorder patients"],"prefix":"10.1111","volume":"121","author":[{"given":"L.","family":"Tondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lepri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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