{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:40:47Z","timestamp":1770478847913,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Nielsen J, Andersen MP, Graff C, Kanters JK, Hardahl T, Dybbro J, Struijk JJ, Meyer JM, Toft E. The effect of sertindole on QTD and TPTE.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak\u2010Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak\u2010Tend are unknown.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Digital 12\u2010lead ECG was recorded at baseline and at steady\u2010state in 37 patients switched to sertindole. ECG was analysed for Fridericia\u2010corrected QT duration (QTcF), QT dispersion and Tpeak\u2010Tend.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> From a baseline QTcF of 407\u2003\u00b1\u200322\u2003ms, mean QTcF prolongation during sertindole treatment was 20\u2003\u00b1\u200323\u2003ms, <jats:italic>P\u2003<\/jats:italic>&lt;\u20030.01. No effect on QTc dispersion was found (\u22121\u2003\u00b1\u200311\u2003ms; <jats:italic>P\u2003<\/jats:italic>=\u20030.41). No increased duration of the Tpeak\u2010Tend interval from baseline was found (+7\u2003\u00b1\u200321\u2003ms; <jats:italic>P\u2003<\/jats:italic>=\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole\u2019s QTc prolonging effects.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2009.01534.x","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T09:17:03Z","timestamp":1263892623000},"page":"385-388","source":"Crossref","is-referenced-by-count":28,"title":["The effect of sertindole on QTD and TPTE"],"prefix":"10.1111","volume":"121","author":[{"given":"J.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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M.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Toft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,13]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000147949"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2004.09.001"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00717-0"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb01185.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1109\/CIC.2007.4745490"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-200015040-00003"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.848"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1425"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199803003-00005"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/026988110101500212"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.80.5.453"},{"key":"e_1_2_9_13_2","first-page":"10","article-title":"Effect of risperidone on QT interval and QT dispersion in the elderly","volume":"2","author":"Yerrabolu M","year":"2000","journal-title":"Heart Dis"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122012896"},{"key":"e_1_2_9_15_2","first-page":"11","article-title":"Sertindole: cardiac electrophysiological profile","volume":"6","author":"Haverkamp W","year":"2002","journal-title":"Int J Psychiatry"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.04.011"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2009.01534.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2009.01534.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:50:11Z","timestamp":1697428211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2009.01534.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,13]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1111\/j.1600-0447.2009.01534.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2009.01534.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,13]]}}}