{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:30:31Z","timestamp":1790933431049,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T00:00:00Z","timestamp":1281830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Linnet J, Peterson E, Doudet DJ, Gjedde A, M\u00f8ller A. Dopamine release in ventral striatum of pathological gamblers losing money.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as \u2018chasing one\u2019s losses\u2019. We therefore hypothesized that losing money would be associated with increased dopamine release in the ventral striatum of PG compared with healthy controls (HC).<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> We used Positron Emission Tomography (PET) with [<jats:sup>11<\/jats:sup>C]raclopride to measure dopamine release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> PG who lost money had significantly increased dopamine release in the left ventral striatum compared with HC. PG and HC who won money did not differ in dopamine release.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our findings suggest a dopaminergic basis of monetary losses in pathological gambling, which might explain loss\u2010chasing behavior. The findings may have implications for the understanding of dopamine dysfunctions and impaired decision\u2010making in pathological gambling and substance\u2010related addictions.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2010.01591.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T04:42:42Z","timestamp":1281933762000},"page":"326-333","source":"Crossref","is-referenced-by-count":104,"title":["Dopamine release in ventral striatum of pathological gamblers losing money"],"prefix":"10.1111","volume":"122","author":[{"given":"J.","family":"Linnet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Doudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gjedde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,15]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"Diagnostic and statistical manual of mental disorders: DSM\u2010IV","author":"DSM\u2010IV","year":"1994"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-6357(03)00150-5"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.110.3.482"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00158-X"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(00)00188-5"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9450.2006.00491.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.01.017"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01380.x"},{"key":"e_1_2_8_10_2","article-title":"Inverse association between dopaminergic neurotransmission and Iowa Gambling Task performance in pathological gamblers and healthy controls","author":"Linnet J","journal-title":"Scand J Psychol"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/30498"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00303-8"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4643-03.2004"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.969"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.2.298-a"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21110"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp054"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(99)00010-1"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021223113233"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00016-7"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(00)00136-6"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.12.2015"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.1.19"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10137"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.9.999"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.6.3072"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00130-4"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.001"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1378"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn2077"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0407-413"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137073"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1600-08.2008"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077349"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.56.091103.070229"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.02.013"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4246-06.2007"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10899-006-9041-5"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3446-06.2006"},{"key":"e_1_2_8_40_2","volume-title":"Structured clinical interview for DSM\u2010IV\u2010TR Axis I disorders, research version, non\u2010patient edition. (SCID\u2010I\/NP)","author":"First M","year":"2002"},{"key":"e_1_2_8_41_2","volume-title":"Structured clinical interview for the DSM\u2010IV Axix I disorders (SCID I\/P, Version 2.0)","author":"First M","year":"1995"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.9.1184"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01015919"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4603(00)00158-1"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(94)90018-3"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.11.2189"},{"key":"e_1_2_8_47_2","volume-title":"Co\u2010planar stereotaxic atlas of the human brain: an approach to cerebral imaging","author":"Talairach J","year":"1988"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(05)63001-2"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200109000-00002"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708002900"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674379804300104"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.158.10.1733"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(03)00117-X"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0504"},{"key":"e_1_2_8_55_2","first-page":"88","article-title":"Pathological gambling: comorbid psychiatric diagnoses in patients and their families","volume":"43","author":"Dannon PN","year":"2006","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02338.x"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10899-006-9016-6"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002479"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2010.01591.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2010.01591.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T17:54:29Z","timestamp":1698774869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2010.01591.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,15]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1111\/j.1600-0447.2010.01591.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2010.01591.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,15]]}}}