{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:37:07Z","timestamp":1790177827351,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Tondo L, Lepri B, Baldessarini RJ. Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Disability varies in patients with major affective disorders [type I and II bipolar disorders (BPD) and recurrent unipolar major depressive disorder (UP\u2010MDD)]. It may include reproductive functioning, which has rarely been studied systematically.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> We compared information acquired over several years pertaining to marital\/reproductive status among 1975 systematically evaluated, treated, and followed women (<jats:italic>n<\/jats:italic>\u2003=\u20031351) and men (<jats:italic>n<\/jats:italic>\u2003=\u2003624) diagnosed with DSM\u2010IV type I (<jats:italic>n<\/jats:italic>\u2003=\u2003300) or II BPD (<jats:italic>n<\/jats:italic>\u2003=\u2003223), or MDD (<jats:italic>n<\/jats:italic>\u2003=\u20031452). We compared factors between patients with vs. without children and associated with fertility rate (children\/fertile years\u2003\u00d7\u2003100), using standard bivariate methods followed by multivariate modeling.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Childless patients were younger at illness onset, more likely men, diagnosed with type I BPD, more educated, and unmarried, but similar in many aspects of clinical history to those with children. Fertility rate ranked: BP\u2010I\u2003&lt;\u2003BP\u2010II\u2003\u2264\u2003MDD, and men\u2003&lt;\u2003women. Mood\u2010disorder patients had 17% fewer children\/person than in the comparable general population of Sardinia. Among mood\u2010disorder patients, fertility appeared to decline in Sardinia in recent decades, more in men than women.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Type I BPD was associated with lower fertility than BP\u2010II or UP\u2010MDD, consistent with their relatively high levels of other disabilities.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2010.01660.x","type":"journal-article","created":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T06:28:26Z","timestamp":1294727306000},"page":"283-289","source":"Crossref","is-referenced-by-count":12,"title":["Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders"],"prefix":"10.1111","volume":"123","author":[{"given":"L.","family":"Tondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lepri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Baldessarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1980.tb00609.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(82)90040-4"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1990.tb01390.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02191155"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm019"},{"key":"e_1_2_9_7_2","volume-title":"Heredity in health and mental disorder","author":"Kallmann FJ","year":"1953"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1963.tb07477.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1966.tb11012.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.01066.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01523.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"crossref","DOI":"10.4054\/MPIDR-WP-2007-033","volume-title":"Fertility and family configurations in Sardinia","author":"Bernardi L","year":"2007"},{"key":"e_1_2_9_13_2","unstructured":"NationMaster.com.Fertility rates by country. Accessible at:http:\/\/www.nationmaster.com\/graph\/peo_tot_fer_rat\u2010people\u2010total\u2010fertility\u2010rate. (accessed February 12 2010)."},{"key":"e_1_2_9_14_2","unstructured":"ISTAT (Italian National Institute of Statistics). 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