{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:38:44Z","timestamp":1780367924916,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T00:00:00Z","timestamp":1319414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Pai NB, Vella SC. Reason for clozapine cessation.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Approximately 30% of individuals diagnosed with schizophrenia suffer from treatment\u2010resistant or refractory schizophrenia. The gold standard for treatment of refractory schizophrenia is clozapine. However, a significant number of patients cease clozapine therapy; therefore this study explores patient\u2019s motives for cessation.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> The motives for cessation and duration of clozapine treatment from a retrospective database of 151 patients with schizophrenia or schizo\u2010affective disorder who had ceased clozapine once or more were reviewed, with the motives for cessation coded. The general motives for cessation were non\u2010compliance, own decision, medical, poor response and other. In addition, the medical reasons for cessation were further codified: cardiac complications, neutropenia, fevers, other side effects and pregnancy.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The majority of patients ceased clozapine owing to non\u2010compliance with medical protocols or citing their own decision. Approximately half ceased after a period of 6\u2003months or less. Seventeen per cent of patients ceased owing to medical reasons, with the largest proportions discontinuing treatment because of other side effects or neutropenia.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Future research should seek to further investigate why patients decide to be non\u2010compliant and formulate their own decision to cease treatment, as this will facilitate strategies to promote adherence amongst these two groups that are potentially the most amenable to change.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2011.01776.x","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T05:18:47Z","timestamp":1319433527000},"page":"39-44","source":"Crossref","is-referenced-by-count":54,"title":["Reason for clozapine cessation"],"prefix":"10.1111","volume":"125","author":[{"given":"N. B.","family":"Pai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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