{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:43:39Z","timestamp":1790376219319,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T00:00:00Z","timestamp":1322611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Lataster J, Myin\u2010Germeys I, Lieb R, Wittchen H\u2010U, van Os J. Adversity and psychosis: a 10\u2010year prospective study investigating synergism between early and recent adversity in psychosis.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Recent studies have suggested that early adverse events, such as childhood trauma, may promote enduring liability for psychosis whereas more recent adverse events may act as precipitants. Examination of these environmental dynamics, however, requires prospective studies in large samples. This study examines whether the association between recent adverse events and psychosis is moderated by exposure to early adversity.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> A random regional representative population sample of 3021 adolescents and young adults in Munich, Germany, was assessed three times over a period of up to 10\u2003years, collecting information on sociodemographic factors, environmental exposures, and measures of psychopathology and associated clinical relevance. Evidence of statistical non\u2010additivity between early adversity (two levels) and more recent adversity (four levels) was assessed in models of psychotic symptoms. Analyses were <jats:italic>a priori<\/jats:italic> corrected for age, gender, cannabis use, and urbanicity.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Early and recent adversity were associated with each other (RR\u2003=\u20031.32, 95% CI 1.06\u20131.66; <jats:italic>P<\/jats:italic>\u2003=\u20030.014) and displayed statistical non\u2010additivity at the highest level of exposure to recent adversity (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u20034.59; <jats:italic>P<\/jats:italic>\u2003=\u20030.032).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The findings suggest that early adversity may impact on later expression of psychosis either by increasing exposure to later adversity and\/or by rendering individuals more sensitive to later adversity if it is severe.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2011.01805.x","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T06:06:31Z","timestamp":1322805991000},"page":"388-399","source":"Crossref","is-referenced-by-count":95,"title":["Adversity and psychosis: a 10\u2010year prospective study investigating synergism between early and recent adversity in psychosis"],"prefix":"10.1111","volume":"125","author":[{"given":"J.","family":"Lataster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Myin\u2010Germeys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010U.","family":"Wittchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van Os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,30]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1925"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09563"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.162.1.72"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2307\/2948405"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.4.298"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn101"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.012179"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2850.2007.01244.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700051503"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.153.3.367"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.07.019"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00782965"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.04.006"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001270170038"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01594.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.168.1.49"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.98.4.407"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(97)00013-7"},{"key":"e_1_2_9_20_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.47102\/annals-acadmedsg.V38N5p402","article-title":"Psychosocial factors in the neurobiology of schizophrenia: a selective review","volume":"38","author":"Lim C","year":"2009","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.04.014"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708004388"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm121"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052043"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018921"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790300029004"},{"key":"e_1_2_9_27_2","volume-title":"DIA\u2010X\u2010Interviews: Manual f\u00fcr Screening\u2010Verfahren und Interview; Interviewheft L\u00e4ngsschnittsuntersuchung (DIA\u2010X Lifetime); Erg\u00e4nzungsheft (DIA\u2010X Lifetime); Interviewheft Querschnittsuntersuchung (DIA\u2010X 12 Monate); Erg\u00e4nzungsheft (DIA\u2010X 12 Monate); PC\u2010Programm zur Durchf\u00fchrung der Interviews (L\u00e4ngs\u2010 und Querschnittsuntersuchung); Auswertungsprogramm","author":"Wittchen H","year":"1997"},{"key":"e_1_2_9_28_2","volume-title":"Composite International Diagnostic Interview (CIDI), Version 1.0","author":"World Health Organization","year":"1990"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(94)90036-1"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1977.tb00241.x"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00805438"},{"key":"e_1_2_9_32_2","volume-title":"Die M\u00fcnchner Ereignisliste (MEL): Anwendungsmanual","author":"Maier\u2010Diewald W","year":"1983"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(89)90059-1"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291705006902"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01539.x"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.10.020"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706009330"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01301.x"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp022"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38267.664086.63"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09060883"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq117"},{"key":"e_1_2_9_43_2","volume-title":"Encyclopedia of stress","author":"Ventura J"},{"key":"e_1_2_9_44_2","volume-title":"Stata Statistical Software: Release 10","author":"StataCorp","year":"2007"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.011346"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08010031"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.440"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.6.885"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.3.216"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf043"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.106.031328"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.020"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009164"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-5573-3-5"},{"key":"e_1_2_9_55_2","volume-title":"Modern epidemiology","author":"Rothman KJ","year":"1986"},{"key":"e_1_2_9_56_2","volume-title":"Modern epidemiology","author":"Rothman KJ","year":"1998"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.41437"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00634.x"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0001-690X.2003.00217.x"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2005.01.004"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10040567"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.147"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq048"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.23"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.12.010"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm163"},{"key":"e_1_2_9_67_2","volume-title":"Search for the causes of schizophrenia","author":"Katschnig H","year":"1991"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/10.2.300"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.86.2.103"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.64.4.319.18602"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91557-W"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10069-2"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3422-03.2004"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb42102.x"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.14.8104"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(96)00102-8"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1068"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91801-9"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9235"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.1.5"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.7.890"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.104.4.667"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00005-8"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00045-2"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/20.3.453"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1391.013"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.13"},{"key":"e_1_2_9_89_2","first-page":"337","article-title":"Breaking secrecy. Adult survivors disclose to their families","volume":"12","author":"Schatzow E","year":"1989","journal-title":"Psychiatr Clin North Am"},{"key":"e_1_2_9_90_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"The American Psychiatric Association","year":"2000"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/22.4.611"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.032408.153506"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/21.1.19"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0447.2011.01805.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0447.2011.01805.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:14:54Z","timestamp":1697408094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0447.2011.01805.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,30]]},"references-count":92,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1600-0447.2011.01805.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0447.2011.01805.x","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,30]]}}}