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Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To evaluate the brain metabolite patterns in patients with fibromyalgia (FM) and somatization disorder (STD) compared with healthy controls through spectroscopy techniques and correlate these patterns with psychological variables.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold>  <jats:italic>Design<\/jats:italic>. Controlled, cross\u2010sectional study. <jats:italic>Sample<\/jats:italic>. Patients were recruited from primary care in Zaragoza, Spain. The control group was recruited from hospital staff. Patients were administered questionnaires on pain catastrophizing, anxiety, depression, pain, quality of life, and cognitive impairment. All patients underwent Magnetic Resonance Imaging and magnetic resonance spectroscopy (MRS).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A significant increase was found in the glutamate\u2003+ glutamine (Glx) levels in the posterior cingulate cortex (PCC): 10.73 (SD: 0.49) for FM and 9.67 (SD: 1.10) for STD 9.54 (SD: 1.46) compared with controls (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.043). In the FM\u2003+\u2003STD group, a correlation between Glx and pain catastrophizing in PCC (<jats:italic>r\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.397; <jats:italic>P\u2003<\/jats:italic>=\u20030.033) and between quality of life and the myo\u2010inositol\/creatine ratio in the left hippocampus (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.500; <jats:italic>P\u2003<\/jats:italic>=\u20030.025) was found. To conclude Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (<jats:sup>1<\/jats:sup>H\u2010MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (<jats:sup>1<\/jats:sup>H\u2010MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2011.01820.x","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T09:51:47Z","timestamp":1325238707000},"page":"115-125","source":"Crossref","is-referenced-by-count":69,"title":["Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study"],"prefix":"10.1111","volume":"126","author":[{"given":"N.","family":"Fayed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Andres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Serrano\u2010Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garcia\u2010Campayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,30]]},"reference":[{"key":"e_1_2_9_2_2","volume-title":"Diagnostic and statistical manual of mental disorders DSM\u2010IV\u2010TR","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10225"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00204-5"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.05.014"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2007.03.015"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1614.2001.00909.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.052"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.001"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.2.394"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24849"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27430"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3072"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.3844\/ajassp.2006.1836.1845"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1157\/13127277"},{"key":"e_1_2_9_17_2","first-page":"233","article-title":"Uso cl\u00ednico del HAD (Hospital Anxiety and Depression Scale) en poblaci\u00f3n psiqui\u00e1trica: un estudio de su sensibilidad, fiabilidad y validez","volume":"13","author":"Tejero A","year":"1986","journal-title":"Rev Dep Psiquiatr Fac Med Barc"},{"key":"e_1_2_9_18_2","first-page":"767","article-title":"Revalidation and standardization of the cognition mini\u2010exam (first Spanish version of the Mini\u2010Mental Status Examination) in the general geriatric population","volume":"112","author":"Lobo A","year":"1999","journal-title":"Med Clin (Barc)"},{"issue":"1","key":"e_1_2_9_19_2","first-page":"79","article-title":"The Spanish version of EuroQol: a description and its applications. 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