{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:24:47Z","timestamp":1790846687455,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T00:00:00Z","timestamp":1337817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Gonz\u00e1lez\u2010Pinto A, Gal\u00e1n J, Mart\u00edn\u2010Carrasco M, Ballesteros J, Maurino J, Vieta E. Anxiety as a marker of severity in acute mania.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Anxiety has scarcely been studied in acute mania. The aim of this study was to assess anxiety symptoms during manic episodes and their impact on clinical outcomes.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Observational, cross\u2010sectional multicentre study. Anxiety was measured using the Hamilton Anxiety Rating Scale (HARS). Bivariate and multiple linear regression analyses were performed using the HARS score as the dependent variable.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Two hundred and forty\u2010two patients admitted with a diagnosis of acute manic episode according to DSM\u2010IV TR criteria and a Young Mania Rating Scale &gt;20 were analysed. Mean age was 43\u2003years (SD\u2003=\u200311.9) and 57% were women. Forty\u2010six per cent of patients (<jats:italic>n<\/jats:italic>\u2003=\u2003104) presented moderate to severe anxiety symptoms (HARS score &gt;14). Anxiety was significantly associated with severity of manic symptoms (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Patients with anxiety had 20% longer hospitalizations (mean 21\u2003days, CI95% 19.7\u201323.7).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> An association of anxiety symptoms with greater severity in acute mania was demonstrated. The close relationship between anxiety and manic symptoms highlights the need for greater clinical attention to anxiety in this population. Further studies are necessary to determine whether effective treatment of anxiety symptoms could improve clinical and care outcomes.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2012.01882.x","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T05:39:31Z","timestamp":1337837971000},"page":"351-355","source":"Crossref","is-referenced-by-count":17,"title":["Anxiety as a marker of severity in acute 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