{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:54:17Z","timestamp":1768521257821,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Bowden CL, Singh V, Weisler R, Thompson P, Chang X, Quinones M, Mintz J. Lamotrigine vs. lamotrigine plus divalproex in randomized, placebo\u2010controlled maintenance treatment for bipolar depression.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To compare the maintenance efficacy of lamotrigine (Lam) to combination therapy of Lam\u2003+\u2003divalproex ER (Div) in recently depressed patients with bipolar disorder (BD).<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> We randomized 86 BD I or II patients in a major depressive episode to 8\u2003months of double\u2010blind treatment with Lam\u2003+\u2003placebo or Lam\u2003+\u2003Div. To be eligible for randomization, patients had to achieve control of both depressive and manic symptoms during an open phase that included both Lam and Div.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Time to depressive episode did not differ significantly by Kaplan\u2013Maier survival analysis (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u20031.82, df\u2003=\u20031, <jats:italic>P<\/jats:italic>\u2003=\u20030.18). However, several secondary outcomes did show significant differences. The proportion of Lam\u2003+\u2003placebo patients who had at least one Montgomery\u2013Asberg Depression Rating Scale (MADRS) score \u226515 during the maintenance phase was 67% (30\/45) compared with 44% (18\/41) for the Lam\u2003+\u2003Div group (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u20034.51, <jats:italic>P<\/jats:italic>\u2003=\u20030.03). Among BD I patients assigned to Lam\u2003+\u2003placebo, 71.4% (25\/35) had at least one visit with MADRS score \u226515 compared with 36.7% (11\/30) among Lam\u2003+\u2003Div patients (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u20037.89, df\u2003=\u20031, <jats:italic>P<\/jats:italic>\u2003=\u20030.005).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Lam\u2003+\u2003Div generally provided greater maintenance efficacy than Lam alone for depressive indices in recently depressed BD patients.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2012.01890.x","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T20:13:31Z","timestamp":1340050411000},"page":"342-350","source":"Crossref","is-referenced-by-count":27,"title":["Lamotrigine vs. lamotrigine plus divalproex in randomized, placebo\u2010controlled maintenance treatment for bipolar depression"],"prefix":"10.1111","volume":"126","author":[{"given":"C. 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