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C\u2010reactive protein, early life stress, and wellbeing in healthy adults.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine whether C\u2010reactive protein (CRP) can serve as a marker for alterations in immune function prior to the manifestation of significant psychiatric and medical disorders.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Ninety\u2010two healthy adults were recruited from the community and determined to be free of psychiatric or medical disorders. The concentration of plasma CRP from a single resting sample was examined in relation to current mental and physical health as well as to self\u2010reported history of early life adversity.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> C\u2010reactive protein showed a significant positive correlation with body mass index (BMI; <jats:italic>r<\/jats:italic>\u2003=\u20030.477, <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). Non\u2010specific pain, fatigue, and lower overall quality of physical health were all associated with higher CRP concentrations (all <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05 or <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01), after controlling for effect of BMI and other relevant covariates. Subthreshold depression symptoms and other indices of mental\/emotional wellbeing were not associated with CRP, nor was CRP significantly linked to any measures of early life adversity.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Lower\u2010quality physical health and wellbeing, but not the presence of mood\/anxiety symptoms or early life stress (ELS), were significantly related to plasma CRP. Elevated CRP does not appear to be a fundamental consequence of ELS among healthy adults.<\/jats:p>","DOI":"10.1111\/j.1600-0447.2012.01892.x","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T06:09:10Z","timestamp":1339394950000},"page":"402-410","source":"Crossref","is-referenced-by-count":45,"title":["C\u2010reactive protein, early life stress, and wellbeing in healthy adults"],"prefix":"10.1111","volume":"126","author":[{"given":"L. L.","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Gawuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Tyrka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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