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To establish this fact the MIC of tetracycline in the presence and absence of reserpine was determined, and, in addition, mechanisms of tetracycline resistance were analyzed by PCR. The results showed that reserpine affects the MIC of tetracycline at least 4\u2010fold in all isolates, including those containing the <jats:italic>tetM<\/jats:italic> gene. An inhibitory effect of reserpine against the MtrCDE efflux system was ruled out by using strains either with an inactive or with an unrepressed MtrCDE system. The results suggest the presence of a constitutive system of resistance to tetracycline, by a possible efflux pump, which may be inhibited by reserpine. Further studies are required to determine the exact nature of the action of reserpine on the MIC of tetracycline.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2005.apm_303.x","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T10:25:46Z","timestamp":1281435946000},"page":"670-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evidence for a reserpine\u2010affected mechanism of resistance to tetracycline in <i>Neisseria 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