{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:05:17Z","timestamp":1765728317382},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T00:00:00Z","timestamp":1148428800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>The importance of androgens and their receptors inhibin and activin remains unknown for mammary epithelial cells. We investigated the role of these hormones in breast apocrine lesions (BAL) using immunohistochemistry to study androgen receptors (AR) and the inhibin\/activin \u03b1 and \u03b2A subunits. Forty\u2010two cases of BAL were evaluated, including 22 cases of fibrocystic disease (FCD) showing prominent apocrine changes, 10 intraductal papillomas with extensive apocrine metaplasia, 5 cases of apocrine carcinoma <jats:italic>in situ<\/jats:italic> (CIS), and 5 cases of apocrine carcinoma. Fifty non\u2010apocrine lesions were included as controls: 20 cases of FCD, 5 cases of DCIS, and 25 cases of invasive ductal carcinoma. AR was more frequently expressed in BAL than in non\u2010apocrine lesions (p=0.001). AR expression was not related to tumor progression. AR showed a significant positive correlation with \u03b2A subunits (r=0.832, p&lt;0.001), and an inverse correlation with \u03b1 subunits (r=\u22120.233). The \u03b1 and \u03b2A subunits demonstrated a significant inverse correlation with each other (r=\u22120.271, p=0.0048). As the expression of the \u03b1 and \u03b2A subunits reflects inhibin and activin A, respectively, AR and activin A may be implicated in apocrine morphogenesis, but not in tumor progression.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2006.apm_321.x","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T13:02:44Z","timestamp":1148475764000},"page":"352-358","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Expression of androgen receptors and inhibin\/activin \u03b1 and \u03b2A subunits in breast apocrine lesions"],"prefix":"10.1111","volume":"114","author":[{"given":"HYO SUB","family":"SHIM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WOO HEE","family":"JUNG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAERYOUNG","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KYEONGMEE","family":"PARK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAM HOON","family":"CHO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01807652"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(97)80053-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-199705000-00001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.11.838"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.24327"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.1996.tb00107.x"},{"key":"e_1_2_6_8_2","first-page":"1","article-title":"Chemical and biochemical characterization of the inhibin family of protein hormones","volume":"44","author":"Vale W","year":"1988","journal-title":"Recent Prog Horm Res"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2235(90)90027-H"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.1.247"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1242\/dev.124.14.2701","article-title":"Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal\u2010epithelial interactions","volume":"124","author":"Robinson GW","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_12_2","first-page":"1155","article-title":"Inhibitory effects of activin on the growth and morphogenesis of primary and transformed mammary epithelial cells","volume":"56","author":"Liu QY","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201017"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410190"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.14.5082"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313020123290"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2004.06.003"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200206000-00008"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-9495-z"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01806496"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6649"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2006.apm_321.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2006.apm_321.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T03:59:17Z","timestamp":1696996757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2006.apm_321.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1600-0463.2006.apm_321.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2006.apm_321.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"2006-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}