{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:41:40Z","timestamp":1791826900322,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>A keratoacanthoma of the vulva in a 33\u2010year\u2010old woman is described. The patient presented with a rapidly growing exophytic lesion of 1 cm in diameter over the clitoris that had been present for a couple of months. An excisional biopsy was performed. Pathologic examination of the exophytic nodule showed squamous proliferation with a characteristic central keratin\u2010 filled crater. There were pushing margins. High power microscopy showed squamous cells of cytologically bland appearance with glassy cytoplasm. There were few mitotic figures. Less than 10% Ki\u201067\u2010positive staining nuclei were seen. There was no p53 oncoprotein overexpression. Keratoacanthoma of the vulva is rare with only five cases having been reviewed in the English literature since 1985. Keratoacanthomas are rapidly growing crateriform lesions on the sun\u2010exposed skin of the elderly. Because of its rarity in the vulva, the lesion can be misinterpreted as a malignant lesion such as squamous cell carcinoma. Awareness of vulvar occurrence of keratoacanthoma and its characteristic histopathologic features will help avoid misdiagnosis of a squamous cell carcinoma leading to radical surgery.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2006.apm_326.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T13:25:04Z","timestamp":1155561904000},"page":"562-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vulvar keratoacanthoma"],"prefix":"10.1111","volume":"114","author":[{"given":"FERDA","family":"OZKAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REMZIYE","family":"BILGI\u00c7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUNA","family":"CESUR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000130044.25477.16"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00026-4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-6053(03)00036-X"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70001-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.12.033"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(85)90242-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903043400906"},{"key":"e_1_2_5_9_2","first-page":"316","volume-title":"World Health Organization of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs","author":"Wilkinson EJ","year":"2003"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1994.tb00720.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089160409000124"},{"key":"e_1_2_5_12_2","first-page":"3019","article-title":"Differential diagnosis of keratoacanthoma and squamous cell carcinoma of the epidermis by MIB\u20101 immunohistometry","volume":"22","author":"Biesterfeld S","year":"2002","journal-title":"Anticancer Res"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-199809000-00001"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2006.apm_326.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2006.apm_326.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:14:20Z","timestamp":1693480460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2006.apm_326.x"}},"subtitle":["Case report and review of the literature"],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":12,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1600-0463.2006.apm_326.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2006.apm_326.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2006-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}