{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T10:30:31Z","timestamp":1718015431801},"reference-count":47,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>This work investigated the possible use of AdDP as adjuvant therapy to praziquantel (PZQ) in mice infected with PZQ\u2010insusceptible <jats:italic>Schistosoma mansoni<\/jats:italic> isolate in a trial to increase the susceptibility of this isolate to the drug. Two batches of C57 BL\/6 mice were infected with PZQ\u2010susceptible and \u2010insusceptible <jats:italic>S. mansoni<\/jats:italic> isolates, and each batch was divided into five groups. Seven weeks postinfection, the experimental group received AdDP (5 mg\/kg) in addition to PZQ in reduced dose (3\u00d7100 mg\/kg). Three of the remaining four groups were treated controls; they received AdDP, PZQ in reduced dose and in full dose (2\u00d7500 mg\/kg), and the fourth group was infected untreated. In mice infected with PZQ\u2010susceptible or \u2010insusceptible <jats:italic>S. mansoni<\/jats:italic> isolate, praziquantel alone, and in addition to AdDP, reduced worm and egg loads and increased percentage dead eggs. Also, they improved the histopathological changes (reduction in granuloma diameter, percentage fibrotic area with increased percentage degenerated eggs). Inducible nitric oxide synthase (iNOS), nitric oxide (NO) in culture of peritoneal macrophages, and number of CD68\u2010positive cells were decreased with improved alanine amino transaminase. In mice receiving combined therapy AdDP+PZQ, the antischistosomal efficacy and the reductions in the inflammatory granulomatous reactions, NO in cultured peritoneal macrophages, percentage fibrotic areas recorded, were comparable to that in mice receiving full dose of PZQ, with significantly higher reduction in CD68 cells denoting enhanced antischistosomal efficacy and healing of the inflammatory reactions in the liver.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2006.apm_380.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T13:25:04Z","timestamp":1155561904000},"page":"480-491","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of adamantylamide dipeptide as adjuvant therapy to praziquantel in mice infected with different <i>S. mansoni<\/i> isolates"],"prefix":"10.1111","volume":"114","author":[{"given":"SANAA","family":"BOTROS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MADIHA","family":"MAHMOUD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLFAT","family":"HAMMAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FATEN","family":"SALAH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZDENEK","family":"ZIDEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAREL","family":"MASEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(92)90264-3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.4049\/jimmunol.149.11.3659","article-title":"IL\u20104 influences IL\u20102 production and granulomatous inflammation in murine S. mansoni","volume":"149","author":"Yamashita T","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.159"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.4049\/jimmunol.163.9.4976","article-title":"Nitric oxide and the Th2 response combine to prevent severe hepatic damage during schistosomal mansoni infection","volume":"163","author":"Brunet LR","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119750"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.003423"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61085-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119782"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190132"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.12.1381691"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119473"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60589-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.4049\/jimmunol.160.12.5729","article-title":"Macrophage\u2010derived nitric oxide regulates T cell activation via reversible disruption of the Jak3\/STAT5 signaling pathway","volume":"160","author":"Bingisser RM","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_5_15_2","first-page":"667","article-title":"The immunomodulatory property of a novel synthetic compound adamantylamide dipeptide","volume":"6","author":"Masek K","year":"1984","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"e_1_2_5_16_2","first-page":"1539","article-title":"The hepatoprotective effect of a new immunomodulator adamntylamide dippeptide on carbon tertrachloride toxicity in rats","volume":"2","author":"Farghali H","year":"1989","journal-title":"Highlights Modern Biochem"},{"key":"e_1_2_5_17_2","first-page":"15","article-title":"Effects of adamantylamide dipeptide (AdDP) on humoral immunity in mice","volume":"8","author":"Zidek Z","year":"1991","journal-title":"Int J Immunother"},{"key":"e_1_2_5_18_2","first-page":"74","article-title":"Effect of adamantylamide dipeptide on reinfection resistance after primary infection eradication in experimental schistosomiasis mansoni","volume":"46","author":"Botros S","year":"1996","journal-title":"Arzneimitt Forsch Drug Res"},{"key":"e_1_2_5_19_2","first-page":"34","article-title":"Laboratory cultivation of schistosome vector snails and maintenance of schistosome life cycles","volume":"1","author":"Liang YS","year":"1987","journal-title":"Proc of the First Sino-American Symposium"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2003.apm1111208.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389899"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"Technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"Duvall RH","year":"1967","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_5_23_2","first-page":"686","article-title":"A suggestion for the prevention of severe clinical forms of schistosomiasis mansoni","volume":"37","author":"Kloetzel K","year":"1967","journal-title":"Bull World Health Organ"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1962.11.201"},{"key":"e_1_2_5_25_2","first-page":"1011","article-title":"Lipolysaccharide\u2010induced changes in plasma nitric and nitric concentration in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors","volume":"272","author":"Tracey WR","year":"1995","journal-title":"J Phamacol Exp Ther"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.11.6172466"},{"key":"e_1_2_5_27_2","first-page":"2408","article-title":"Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas","volume":"6","author":"Vakkala M","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00215-6"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00259-6"},{"key":"e_1_2_5_30_2","unstructured":"PerperRJ WoodD ZimmermanM.Immunopharmacology. In:RosenthaleME MansmannHCeds..Spectrum Publications Inc.: New York 1975:15\u201329."},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1994.11812881"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-322R"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90064-Z"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000065069"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006460X"},{"key":"e_1_2_5_36_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1017\/S003118200007534X","article-title":"Immune\u2010dependent chemotherapy of schistosomiasis","volume":"105","author":"Fallon PG","year":"1992","journal-title":"Parasitology"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(89)90001-7"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220622"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00068-0"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(93)90081-9"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-100108597"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.49.31138"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.52.4.390"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.3.1430"},{"key":"e_1_2_5_45_2","first-page":"82","article-title":"Nitrogen oxide protects against cellular damage by reactive oxygen species","volume":"221","author":"Wink D","year":"1995","journal-title":"Review. Toxicol lett"},{"key":"e_1_2_5_46_2","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.4049\/jimmunol.157.11.5009","article-title":"Eosinophils from schistosome\u2010induced hepatic granulomas produce superoxide and hydroxyl radical","volume":"157","author":"McCormick M","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021909902310"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1377"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2006.apm_380.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2006.apm_380.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:13:23Z","timestamp":1693480403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2006.apm_380.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":47,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1600-0463.2006.apm_380.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2006.apm_380.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2006-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}