{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T16:37:35Z","timestamp":1726159055552},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T00:00:00Z","timestamp":1159401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>C4d deposition in the walls of peritubular capillaries is considered the key phenomenon in the histopathological diagnosis of humoral, i.e. antibody\u2010mediated, allograft rejection. We have earlier proposed that deposition of C3c in glomerular capillaries and simultaneous intravascular accumulation of macrophages in allografts with immediate or early humoral rejection indicates a potentially serious condition with very poor prognosis. The clinical outcome of 45 cadaveric grafts with this phenomenon among 1960 renal allografts transplanted at our centre during 1984\u20131999, and the recipients of the contralateral kidneys, was retrospectively evaluated. Graft failure occurred in 44\/45 grafts within 3 weeks, with graft loss in 33\/45 (77%) within 4 months and 37\/45 (82%) within 1 year. From the contralateral kidneys, 5\/33 (15%) were lost within 1 year. In a recent series of early biopsies, we recognised that of 13 cases showing C4d positivity in peritubular capillaries but lacking C3c in glomeruli, 10\/13 (77%) were still functioning after 4 months. The mean number of CD68<jats:sup>+<\/jats:sup> macrophages per glomerular profile, i.e. the glomerular macrophage index, shows a significant difference between C4d<jats:sup>+<\/jats:sup>C3c<jats:sup>\u2212<\/jats:sup> and C4d<jats:sup>+<\/jats:sup>C3c<jats:sup>+<\/jats:sup> cases (p&lt;0.001). Our results indicate the existence of a clinically important subgroup of early humoral rejection with particular morphological features.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2006.apm_422.x","type":"journal-article","created":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T08:12:53Z","timestamp":1159431173000},"page":"700-711","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Glomerular C3c deposition and intravascular macrophage accumulation in early humoral renal allograft rejection signifies a poor short\u2010term outcome"],"prefix":"10.1111","volume":"114","author":[{"given":"JOHAN","family":"M\u00d6LNE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GUDRUN","family":"NYBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"INGEMAR","family":"BLOHM\u00c9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LENNART","family":"RYDBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL E.","family":"BREIMER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTIAN T.","family":"SVALANDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,28]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"12","article-title":"Acute humoral rejection in kidney transplantation (Review)","volume":"3","author":"Crespo M","year":"2000","journal-title":"Graft"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199001000-00019"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb02954.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V10102208"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00043-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.10.2058"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1681\/ASN.V131242","article-title":"Detection of the complement degradation product C4d in renal allografts: diagnostic and therapeutic implications","volume":"13","author":"Nickeleit V","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1681\/ASN.V131234","article-title":"C4d deposition in acute rejection: an independent long\u2010term prognostic factor","volume":"13","author":"Herzenberger AM","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209150-00021"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg304"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.460"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00072.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199606150-00007"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1681\/ASN.V133779","article-title":"Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification","volume":"13","author":"Mauiyyedi S","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_16_2","first-page":"903","article-title":"Acute early allograft failure and the C3\/macrophage phenomenon","volume":"25","author":"Svalander CT","year":"1993","journal-title":"Transplant Proc"},{"key":"e_1_2_6_17_2","first-page":"338","article-title":"Activation of intravascular macrophages within myocardial small vessels is a feature of acute vascular rejection in human heart transplants","volume":"14","author":"Ratliff NB","year":"1995","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00921.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2001.091204.x"},{"key":"e_1_2_6_20_2","first-page":"421","article-title":"Macrophages and C3 deposition in early biopsies as a sign of poor prognosis in human graft rejection","volume":"20","author":"Hedman L","year":"1988","journal-title":"Transplant Proc"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1986.tb00500.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00299.x"},{"key":"e_1_2_6_23_2","first-page":"1","volume-title":"The Macrophage","author":"Ross JA","year":"2002"},{"key":"e_1_2_6_24_2","first-page":"1359","article-title":"PG\u2010M1: A new monoclonal antibody directed against a fixative\u2010resistent epitope on the macrophage\u2010restricted form of the CD68 molecule","volume":"142","author":"Falini B","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00493425"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.019"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2003.tb00241.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000062835.30165.2C"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000069040.16457.06"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00137-6"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198908000-00011"},{"key":"e_1_2_6_32_2","first-page":"1293","article-title":"Diagnostic value of monocyte\/macrophage (WT14) staining in renal allograft biopsies","volume":"23","author":"Bogman MJJT","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_6_33_2","first-page":"288","article-title":"Practical guidelines for fine needle aspiration biopsy of human renal allografts","volume":"13","author":"H\u00e4yry P","year":"1981","journal-title":"Ann Clin Res"},{"key":"e_1_2_6_34_2","first-page":"198","article-title":"Immunophenotype of vascular rejection in renal transplants","volume":"3","author":"Alpers CE","year":"1990","journal-title":"Modern pathology"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.02.017"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP62121"},{"key":"e_1_2_6_37_2","first-page":"151","article-title":"Clinical\u2010pathologic features of humoral rejection in cardiac allografts: a study in 81 consecutive patients","volume":"14","author":"Lones MA","year":"1995","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_6_38_2","first-page":"321","volume-title":"Immunologic renal diseases","author":"Clayberger C","year":"2001"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2006.apm_422.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2006.apm_422.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:00:59Z","timestamp":1697040059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2006.apm_422.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,28]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1600-0463.2006.apm_422.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2006.apm_422.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,28]]},"assertion":[{"value":"2006-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}