{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:30:53Z","timestamp":1759941053772},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T00:00:00Z","timestamp":1162252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>The aim of the study was to estimate the degree of lung damage in patients with \u03b1<jats:sub>1<\/jats:sub>\u2010antitrypsin (\u03b11AT) deficiency, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) at the time of lung transplantation. Using unbiased stereological methods, lung\u2010, bronchial\u2010 and vessel\u2010volume, capillary length, and alveolar surface area and densities were estimated in recipient lungs from 21 consecutive patients with pre\u2010transplant diagnoses including COPD (n=7), \u03b11AT deficiency (n=6) and CF (n=8). Six unused adult donor lungs served as controls. Information relating to patient demography and pre\u2010transplant lung function was obtained by retrospective chart review. Disease groups differed significantly with respect to demographics and pre\u2010transplant lung function. Total lung volume was similar in all groups. Bronchial volume was significantly larger in CF patients compared to the control group (p&lt;0.0001) and to the other two diagnostic groups: \u03b11AT deficiency (p=0.0001) and COPD (p&lt;0.0001). Alveolar surface density and capillary length density were significantly lower in patients with \u03b11AT deficiency and COPD compared to controls (p&lt;0.0001, respectively) and to patients with CF (p&lt;0.0002, respectively). There were no correlations between clinical lung function and morphometric measurements. We conclude that unbiased microscopic stereological morphometry is an evolving science with the potential to elucidate pulmonary disease pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2006.apm_508.x","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T12:42:21Z","timestamp":1162298541000},"page":"795-804","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Morphometric examination of native lungs in human lung allograft recipients"],"prefix":"10.1111","volume":"114","author":[{"given":"B. M.","family":"WIEBE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"BURTON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"MILMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"IVERSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. B.","family":"ANDERSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06405-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00352-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.05.019"},{"key":"e_1_2_5_5_2","first-page":"1047","article-title":"Measurement of health\u2010related quality of life before and after heart\u2010lung transplantation","volume":"15","author":"Caine N","year":"1996","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.001"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070320308"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1998.tb01395.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1988.tb05320.x"},{"key":"e_1_2_5_10_2","volume-title":"Lecture Notes in Biomathematic","author":"Gundersen HJ","year":"1978"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00261706"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9903138"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.3.563"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-659OC"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19960815)34:6<556::AID-JEMT8>3.0.CO;2-H"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.32.4.483"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.3.144"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000043519.29370.C2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.2.308"},{"key":"e_1_2_5_20_2","first-page":"764","article-title":"Destructive index: a measurement of lung parenchymal destruction in smokers","volume":"131","author":"Saetta M","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2.626"},{"key":"e_1_2_5_22_2","first-page":"999","article-title":"Morphometry of the human lung: the state of the art after two decades","volume":"15","author":"Weibel ER","year":"1979","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_2_5_23_2","first-page":"535","article-title":"Regional distribution of macroscopic lung disease in cystic fibrosis","volume":"133","author":"Tomashefski JF","year":"1986","journal-title":"Am Rev Respir Dis"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2006.apm_508.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2006.apm_508.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:51:33Z","timestamp":1697039493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2006.apm_508.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,31]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1600-0463.2006.apm_508.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2006.apm_508.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,31]]},"assertion":[{"value":"2006-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}