{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:40Z","timestamp":1787755480922,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T00:00:00Z","timestamp":1146700800000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>In this study we examined the proliferative enteropathy, caused by the obligate intracellular bacterium<jats:italic>Lawsonia intracellularis,<\/jats:italic>in colon of naturally infected pigs, using immunohistochemistry,<jats:italic>in situ<\/jats:italic>hybridisation and scanning confocal laser microscopy. When 396 pigs submitted for routine laboratory examination were investigated, large intestinal gross lesions were seen in 93, including 74 cases of<jats:italic>L. intracellularis<\/jats:italic>colitis (proliferative enteropathy). Fifty\u2010one pigs without recorded colonic gross lesions revealed<jats:italic>L. intracellularis<\/jats:italic>colitis microscopically. In four cases,<jats:italic>L. intracellularis<\/jats:italic>was only revealed in colon. Fifty\u2010seven pigs were positive for<jats:italic>L. intracellularis<\/jats:italic>in the small intestines only. Thus, the overall prevalence of colonic infection in<jats:italic>L. intracellularis<\/jats:italic>\u2010positive animals was as high as 69% (125 out of 182). In comparison, the large intestinal pathogens<jats:italic>Brachyspira hyodysenteriae<\/jats:italic>and<jats:italic>Salmonella enterica<\/jats:italic>were only isolated from 5 and 4 of the 93 cases, respectively. Morphologically, an unforeseen severe involvement of the subepithelial mucosa with multiple<jats:italic>L. intracellularis<\/jats:italic>found free and within large macrophages was observed in areas with acute infection. The distribution of whole<jats:italic>L. intracellularis<\/jats:italic>organisms was confirmed by<jats:italic>in situ<\/jats:italic>hybridisation and scanning confocal laser microscopy. The significance and possible role of subepithelial infection in the proliferative enteropathy is discussed. In conclusion, the study shows that<jats:italic>L. intracellularis<\/jats:italic>is a prevalent cause of naturally acquired colitis in pigs.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2006.apm_53.x","type":"journal-article","created":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T09:57:59Z","timestamp":1146736679000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Lawsonia intracellularis<\/i>infection in the large intestines of pigs"],"prefix":"10.1111","volume":"114","author":[{"given":"T. K.","family":"JENSEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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