{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:14:50Z","timestamp":1779282890149,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>NOTCH proteins (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) play crucial roles in embryonic development. Also, mounting evidence indicates that NOTCH contributes to the pathogenesis of hematopoietic and solid malignancies. Recent studies reported a high incidence of gain\u2010of\u2010function mutations of the <jats:italic>NOTCH1<\/jats:italic> gene in T\u2010cell acute lymphoblastic leukemias (ALL). To see whether <jats:italic>NOTCH1<\/jats:italic> mutation occurs in other malignancies, we analyzed <jats:italic>NOTCH1<\/jats:italic> for the detection of somatic mutations in 334 malignancies, including 48 lung, 48 breast, 48 colorectal and 48 gastric carcinomas, and 142 acute leukemias (105 acute myelogenous leukemias, 32 B\u2010ALLs and 4 T\u2010ALLs) by single\u2010strand conformation polymorphism assay. Also, to see whether other <jats:italic>NOTCH<\/jats:italic> genes harbor somatic mutations, we analyzed <jats:italic>NOTCH2, NOTCH3<\/jats:italic> and <jats:italic>NOTCH4<\/jats:italic> genes in the same tissue samples. Overall, we detected three <jats:italic>NOTCH<\/jats:italic> mutations in the cancers, which consisted of one <jats:italic>NOTCH1<\/jats:italic> mutation in the T\u2010ALLs (25.0%), one <jats:italic>NOTCH2<\/jats:italic> mutation in the breast carcinomas (2.1%), and one <jats:italic>NOTCH3<\/jats:italic> mutation in the colorectal carcinomas (2.0%). There was no <jats:italic>NOTCH<\/jats:italic> mutation in other malignancies analyzed. Our data indicate that <jats:italic>NOTCH1<\/jats:italic> is mutated in T\u2010ALL, but not in other common human cancers, and that <jats:italic>NOTCH2<\/jats:italic>, <jats:italic>NOTCH3<\/jats:italic> and <jats:italic>NOTH4<\/jats:italic> genes are rarely mutated in common human cancers. Despite the importance of NOTCH activation in many types of human cancers, mutation of <jats:italic>NOTCH<\/jats:italic> genes, except for <jats:italic>NOTCH1<\/jats:italic> mutation in T\u2010ALL, may not play an important role in the tumorigenesis of common cancers.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2007.00751.x","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T12:42:30Z","timestamp":1224074550000},"page":"1357-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mutational analysis of <i>NOTCH1, 2, 3<\/i> and <i>4<\/i> genes in common solid cancers and acute leukemias"],"prefix":"10.1111","volume":"115","author":[{"given":"SUNG HAK","family":"LEE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EUN 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