{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T06:48:55Z","timestamp":1785653335007,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Up to 30% of cervical intraepithelial grades 2\u20133 (CIN2\u20133) lesions regress, but some believe that \u201cregression\u201d is due to \u201ccurative\u201d punch biopsies. If this is true, CIN2\u20133 in the resection margins of the biopsies would be associated with more frequent \u201cpersistent\u201d CIN2\u20133. If, however, immunology\u2010related regression exists, regression would increase with increasing biopsy\u2010cone interval. In 61 punch biopsies diagnosed as CIN3 at careful review by two independent gynaecological pathologists, CIN3 in the resection margins and duration of the biopsy\u2010cone interval was evaluated in relation to CIN2\u20133\u2010or\u2010not in the cones (again after independent review by expert pathologists). 10 of 61 (16%) patients with CIN3 showed CIN1 or less in the follow\u2010up cones. CIN3\u2010or\u2010not in the resection margins, size of the lesion in the punch biopsy, and presence or absence of CIN2\u20133 in the cones were not correlated with regression\u2010or\u2010not. However, the number of cones without CIN2\u20133 increased with longer biopsy\u2010cone interval, 5% in patients with a punch\u2010cone biopsy interval under 9 weeks and 38%\u22659 weeks (p&lt;0.001). These results favour the hypothesis that CIN3 can regress, and do not support the \u201ccurative punch biopsy\u201d theory.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2007.00769.x","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T12:42:30Z","timestamp":1224074550000},"page":"1409-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Cervical intraepithelial neoplasia grade 3 lesions can regress"],"prefix":"10.1111","volume":"115","author":[{"given":"ANE CECILIE","family":"MUNK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARNOLD\u2010JAN","family":"KRUSE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BIANCA","family":"VAN DIERMEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMIEL A. 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