{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:24:31Z","timestamp":1761708271796,"version":"3.40.3"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Histologically, benign lymphoid hyperplasia (BLH) of the rectum is usually characterized by large lymphoid follicles with active germinal centers, and a narrow surrounding mantle zone and marginal zone. We present two cases of BLH of the rectum demonstrating progressive transformation of the germinal center (PTGC). The patients were 50\u2010 and 71\u2010year\u2010old Japanese women. Colonoscopy demonstrated small sessile polyps in both cases. The resected specimen contained numerous lymphoid follicles with active germinal centers and a portion of the lymphoid follicles exhibited PTGC. The area showing PTGC contained a few large lymphoid cells resembling lymphocytic and histiocytic Reed\u2010Sternberg cells of nodular lymphocyte\u2010predominant Hodgkin lymphoma. These PTGC contained small\u2010 to\u2010medium clusters of epithelioid cells in both cases. <jats:italic>In situ<\/jats:italic> hybridization studies demonstrated scattered Epstein\u2010Barr virus (EBV)\u2010encoded small RNA\u2010positive medium and large lymphoid cells and crypt epithelium in both lesions. EBV may be involved in the etiology of a subset of BLH of the rectum. However, reactivity of lymphoid cells for EBV has been reported in lymphoid tissues in a high percentage of \u201cnormal\u201d individuals. The etiology of BLH of the rectum remains unclear.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2007.00815.x","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T12:42:30Z","timestamp":1224074550000},"page":"1432-1436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Localized lymphoid hyperplasia of the rectum representing progressive transformation of the germinal center"],"prefix":"10.1111","volume":"115","author":[{"given":"MASARU","family":"KOJIMA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MISA","family":"IIJIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUHIKO","family":"SHIMIZU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUE","family":"HOSHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197812000-00005"},{"key":"e_1_2_6_3_2","first-page":"102","volume-title":"Tumor of the Intestine (Atlas of Tumor Pathology, 3rd series, Fascicle 32)","author":"Riddell RH","year":"2003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2005.07.007"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81092-3_1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199901000-00003"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1982.tb02702.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1988.tb01939.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199109000-00001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1994.tb00537.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.4.488"},{"key":"e_1_2_6_12_2","first-page":"139","article-title":"Non\u2010Hodgkin's lymphomas of mantle zone origine","volume":"26","author":"Weisenburger DD","year":"1991","journal-title":"Pathol Ann"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200202000-00008"},{"key":"e_1_2_6_14_2","first-page":"626","article-title":"Histological variety of floral variant of follicular lymphoma","volume":"114","author":"Kojima M","year":"2006","journal-title":"A report of 13 Japanese cases. APMIS"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1995.tb01419.x"},{"key":"e_1_2_6_16_2","first-page":"162","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid tissues","author":"Stein H","year":"2001"},{"key":"e_1_2_6_17_2","first-page":"1259","article-title":"Epstein\u2010Barr virus and Hodgkin's disease. A correlative in situ hybridizationand polymerase chain reaction study","volume":"139","author":"Weiss LM","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800369"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2007.00815.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2007.00815.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T09:30:22Z","timestamp":1744191022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2007.00815.x"}},"subtitle":["A report of two cases"],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1600-0463.2007.00815.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2007.00815.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"type":"print","value":"0903-4641"},{"type":"electronic","value":"1600-0463"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"2007-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}