{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:06:18Z","timestamp":1761523578418},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T00:00:00Z","timestamp":1196035200000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>Gene expression profiling is a powerful tool to uncover complex molecular networks in cancer and, specifically, in malignant lymphomas. Within diffuse large B\u2010cell lymphomas (DLBCL), two major molecular subtypes, the activated B\u2010cell\u2010like (ABC) and the germinal center B\u2010cell\u2010like (GCB) DLBCL, can be defined. Compared to GCB DLBCL, ABC DLBCL shows a vast difference in gene expression and constitutively expresses NF\u03baB and its target genes. In retrospective analyses, the molecular phenotype of ABC DLBCL is associated with inferior survival. Gene expression profiling furthermore allows the molecular separation of Burkitt lymphoma (BL) from DLBCL and reveals a Burkitt\u2010specific signature which is also expressed by a subset of tumors that are currently classified as DLBCL. Whether patients with a DLBCL displaying a Burkitt\u2010specific gene expression signature may benefit from alternative therapeutic approaches will have to be determined in future prospective clinical trials.<\/jats:p><jats:p>In follicular lymphoma (FL), two outcome\u2010related signatures, termed Immune response 1 (IR1) and Immune response 2 (IR2), have been identified by gene expression profiling, indicating a significant role of the microenvironment in tumor development and progression. IR1, composed of genes mostly expressed by T\u2010cells, was found to be associated with a more favorable clinical course, and IR2, enriched for genes expressed by macrophages and follicular dendritic cells, was found to be associated with an inferior clinical course. In mantle cell lymphoma (MCL), a gene expression\u2010based proliferation signature of 20 different genes was identified that is able to predict survival of MCL patients in a linear fashion. Future efforts will have to be directed towards the translation of relevant molecular diagnostic and prognostic markers derived from the wealth of gene expression data into clinical tests and towards the development of novel, targeted therapies.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2007.apm_867.xml.x","type":"journal-article","created":{"date-parts":[[2007,12,2]],"date-time":"2007-12-02T23:50:46Z","timestamp":1196639446000},"page":"1135-1146","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Diagnostic and prognostic significance of gene expression profiling in lymphomas"],"prefix":"10.1111","volume":"115","author":[{"given":"ELLEN","family":"LEICH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELENA MARIA","family":"HARTMANN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"CHRISTOF BUREK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERMAN","family":"OTT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREAS","family":"ROSENWALD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,26]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.015"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.945"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1136"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.1.244"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.1.265.265"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/84GE-U85A-FMU0-7AUV"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.4490"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2554"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2285"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1399"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.28.11.1"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1861"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4222"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190601078605"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1510"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2365"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0102-68"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2947"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1732008100"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00429.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06375.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800396"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1286"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200404000-00005"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.15.503"},{"key":"e_1_2_8_32_2","first-page":"341","article-title":"Identification of outcome predictors in diffuse large B\u2010cell lymphoma. Immunohistochemical profiling of homogeneously treated de novo tumors with nodal presentation on tissue micro\u2010arrays","volume":"90","author":"Zinzani PL","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032520"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.3.925"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf253"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi403"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.21.3707"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204595"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.019"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.26.856"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404426"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041869"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06439.x"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1137463100"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2298"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132253599"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.1648"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4642"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1565"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-018218"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1734"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.019"},{"key":"e_1_2_8_56_2","first-page":"115","article-title":"Mantle\u2010cell lymphoma","volume":"36","author":"Campo E","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402272"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<567::AID-CNCR20>3.0.CO;2-Z"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4079"},{"key":"e_1_2_8_60_2","first-page":"4608","article-title":"Alterations of the cyclin D1\/p16\u2010pRB pathway in mantle cell lymphoma","volume":"57","author":"Dreyling MH","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.8.2977.2977_2977_2984"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.10.4302.bloodjournal87104302"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.3.787"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00028-X"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1753"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.4251"},{"key":"e_1_2_8_67_2","first-page":"8226","article-title":"The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival","volume":"63","author":"Martinez N","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(94)00129-X"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05630.x"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015586"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057208"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2007.apm_867.xml.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2007.apm_867.xml.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:36:15Z","timestamp":1697049375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2007.apm_867.xml.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0463.2007.apm_867.xml.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2007.apm_867.xml.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"2007-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}