{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:49:25Z","timestamp":1784288965888,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T00:00:00Z","timestamp":1227225600000},"content-version":"vor","delay-in-days":204,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>In the <jats:italic>Neisseria meningitidi<\/jats:italic>s strain MC58 (serogroup B; ET\u20105 complex) genome three putative islands of horizontally transferred DNA (IHTs) have been identified. IHT\u2010A2 codes for eight hypothetical proteins and two disrupted open reading frames with similarity to a secretion protein (NMB0097) and an ABC transporter (NMB0098). The strains MC58 and 44\/76 (shown here) are meningocin resistant\/weakly sensitive. None of these strains are meningocin producers. However, NMB0097 and NMB0098 homologues with open reading frames are found in meningocin producers (<jats:italic>N. meningitidis <\/jats:italic>P241 (serogroup A; systemic isolate) and BT878 (serogroup B; carrier isolate), and also in strain FAM18 (serogroup C; ET\u201037 complex). Knocking out either of the two genes in the strain BT878 yielded mutants that did not secrete meningocin. A similarly disrupted <jats:italic>tolC<\/jats:italic> mutant in strain BT878 still released meningocin. Among systemic meningococcal isolates prior to and at the onset (mid\u20101973 to the end of 1974) of the epidemic peaking in 1975 in North Norway, 12 of 30 (40%) isolates of serogroup A were meningocin producers. However, the rate for serogroup B was 1 of 45 (2.2%). Serogroup B meningocin\u2010resistant\/weakly sensitive non\u2010producers dominated in the region from mid\u20101975 and spread to the rest of the country from then on. No producers were found in selected pharyngeal isolates from healthy carriers collected in Svalbard in the early spring of 1975. Our results suggest that meningocinogeny has played a part in the change from serogroup A to serogroup B among isolates in North Norway during the first half of 1975.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2008.00850.x","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T17:09:22Z","timestamp":1209575362000},"page":"333-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bacteriocins (meningocins) in Norwegian isolates of <i>Neisseria meningitidis:<\/i> possible role in the course of a meningococcal epidemic"],"prefix":"10.1111","volume":"116","author":[{"given":"JURIS","family":"ALLUNANS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KNUT IVAN","family":"KRISTIANSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REZA","family":"ASSALKHOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAGNAR","family":"BJ\u00d8R\u00c5S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2006.00052.x"},{"key":"e_1_2_6_3_2","first-page":"107","article-title":"Expression of bacteriocin\u2010like activity in batch cultures of Neisseria meningitidis and consequences for genetic recombination","volume":"91","author":"Jyssum K","year":"1983","journal-title":"Acta Path Microbiol Immunol Scand Sect B"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1574-6968.1992.tb05725.x","article-title":"Transformation\u2010mediated exchange of virulence determinants by co\u2010cultivation of pathogenic Neisseriae","volume":"100","author":"Frosch M","year":"1992","journal-title":"FEMS Microbiol Lett"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.3.545"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.8.2570-2575.2001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026061"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2508(00)00168-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4927"},{"key":"e_1_2_6_10_2","volume-title":"Methods in molecular medicine, vol 67: Meningococcal disease. 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