{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:19:08Z","timestamp":1778498348898,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T00:00:00Z","timestamp":1207267200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>We report the clinical and histopathological characteristics of two cases of signet ring cell carcinoma of the eye lids, and discuss the histogenesis of this neoplasm. Two 72\u2010year\u2010old Caucasian males both presented with slowly growing tumours of the eyelids. The tumours were excised and specimens were examined using light\u2010 and transmission electron microscopic techniques. Clinically, the tumours infiltrated both eyelids on one side of the face with swelling and periocular inflammation, creating a monocle\u2010like appearance. Extensive clinical work\u2010up excluded periocular metastases. Histopathologically, the tumours were composed of rather bland cells with mainly histiocytoid morphology. A minor proportion had a signet ring cell appearance. The cytoplasmic inclusions giving the signet ring morphology were PAS\u2010 and colloidal iron positive. The tumour cells reacted with antibodies against cytokeratins, carcinoembryonic antigen, epithelial membrane antigen, gross cystic disease fluid protein\u201015 and lysozyme. Transmission electron microscopy demonstrated tumour cells containing intracytoplasmic vacuoles lined by microvilli. The tumour cells aggregated in duct\u2010like clusters. A diagnosis of primary signet ring cell carcinoma was made in both cases. Histopathological, immunohistological and ultrastructural findings indicated that the tumours were of sweat gland origin.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2008.00880.x","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T13:59:16Z","timestamp":1207317556000},"page":"326-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Signet ring cell carcinoma of the eyelid \u2013 the monocle tumour"],"prefix":"10.1111","volume":"116","author":[{"given":"ANOUCK LEUBA","family":"MORTENSEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEFFEN","family":"HEEGAARD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLE","family":"CLEMMENSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN ULRIK","family":"PRAUSE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<1034::AID-CNCR2820360329>3.0.CO;2-G"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)34576-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200108000-00009"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(97)80031-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.039"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199902000-00009"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb03495.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30426-0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)01003-X"},{"key":"e_1_2_6_11_2","first-page":"166","article-title":"Morphology and development of an apoeccrine sweat gland in human axillae","volume":"252","author":"Sato K","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199402000-00005"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199506000-00006"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200110000-00010"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.5227\/skincancer.11.210"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02231.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70271-5"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1987.tb00477.x"},{"key":"e_1_2_6_19_2","first-page":"221","article-title":"Sweat gland carcinoma with metastases to the skin: Response to 5\u2010fluorouracil chemotherapy","volume":"55","author":"Bellman B","year":"1995","journal-title":"Cutis"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930310105"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1976.03910040779012"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(79)90188-0"},{"key":"e_1_2_6_23_2","first-page":"112","article-title":"Signet ring cell carcinoma of the eccrine sweat gland in the eyelid, treated by radiotherapy alone","volume":"85","author":"Auw\u2010Haedrich C","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_6_24_2","first-page":"739","article-title":"Eccrine sweat glands carcinoma of the eyelid","volume":"76","author":"Gonzalo BE","year":"2001","journal-title":"Arch Soc Esp Oftalmol"},{"key":"e_1_2_6_25_2","first-page":"547","article-title":"Primary signet ring cell carcinoma of the eccrine sweat gland in the eyelid. 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