{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:07:23Z","timestamp":1770509243653,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:00:00Z","timestamp":1218585600000},"content-version":"vor","delay-in-days":73,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>The aim of the study was to establish possible factors which play a role in progression of gastritis to atrophic gastritis in long\u2010term follow\u2010up among the Estonian population, to assess the association between the host immune response and different <jats:italic>Helicobacter pylori<\/jats:italic> antigens and autoantigens in relation to the histological parameters of gastritis in the antrum and corpus. ELISA and immunoblot were used for detection of IgG to <jats:italic>H. pylori<\/jats:italic> acid glycine\u2010extracted cell surface proteins, CagA protein, and <jats:italic>H. pylori <\/jats:italic>HSP60. Anticanalicular autoantibodies (ACAB) in the serum were evaluated according to Faller et al. (1996). Apoptosis was evaluated using the TUNEL method. Study subjects were 1958 persons from an unselected Estonian population, and 70 persons from a sample from Saaremaa Island, who had been investigated over a period of 18 years. Seropositivity for CagA was a sign of gastritis activity [OR=14.8 (4.5\u201350.3)] and atrophy [OR=7.0 (2.1\u201323.1)] and might predict development of atrophy, particularly in the corpus [OR=7.1 (1.8\u201327.7)]. The prevalence of ACAB increased significantly with duration of <jats:italic>H. pylori<\/jats:italic> gastritis from 22% in 1985 to 46% in 1997 (p=0.004). Immune response to <jats:italic>H. pylori<\/jats:italic> HSP60 indicates chronic inflammation in the antrum (p=0.003). Apoptosis of gastric epithelial cells is largely dependent on grade of activity of gastritis, and, particularly in the antrum, on grade of <jats:italic>H. pylori<\/jats:italic> colonization (p=0.01; p=0.02), but is not associated with development of atrophy. Seropositivity for different <jats:italic>H. pylori<\/jats:italic> antigens (CagA, HSP 60) serves as a marker of different histological manifestations in the antrum and corpus mucosa.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2008.00934.x","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T14:59:29Z","timestamp":1218639569000},"page":"465-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Immune response to <i>Helicobacter pylori<\/i> and its association with the dynamics of chronic gastritis in the antrum and corpus"],"prefix":"10.1111","volume":"116","author":[{"given":"TAMARA","family":"VOROBJOVA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HEIDI\u2010INGRID","family":"MAAROOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAIVO","family":"UIBO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,13]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.244"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1868"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1998.00005.x"},{"key":"e_1_2_11_6_2","first-page":"137","article-title":"Gastritis and its relation to gastric carcinogenesis","volume":"8","author":"Wyatt JI","year":"1991","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409091404"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529008997627"},{"key":"e_1_2_11_9_2","first-page":"229","article-title":"Differences in Helicobacter pylori associated gastritis in antrum and body of the stomach","volume":"28","author":"Stolte M","year":"1990","journal-title":"Z Gastroenterol"},{"key":"e_1_2_11_10_2","first-page":"89","article-title":"Relationship between the degree of Helicobacter pylori colonization and the degree and activity of gastritis, surface epithelial degeneration and mucus secretion","volume":"33","author":"Stolte M","year":"1995","journal-title":"Z Gastroenterol"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i7.976"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90126-J"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1996.22164003.x"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.5.367"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1549-9"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2006.00440.x"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01761.x"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050232"},{"key":"e_1_2_11_19_2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/00365521.1976.12097193","article-title":"Prevalence of antral and fundic gastritis in a randomly selected group of an Estonian rural population","volume":"11","author":"Villako K","year":"1976","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529109104000"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199406000-00014"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199801000-00008"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1995.tb00079.x"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025318"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000202"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750065870"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2001.tb01563.x"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00199508"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02936382"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22435"},{"key":"e_1_2_11_32_2","first-page":"131","volume-title":"Cancer in Estonia 1968\u20131992. Incidence, mortality, prevalence, survival. Published by the Institute of Experimental and Clinical Medicine","author":"Thomson H","year":"1996"},{"key":"e_1_2_11_33_2","unstructured":"LangK.Cancer in Estonia: Rates and Validity.PhD thesis University of London: London 2005; pp.293."},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90477-7"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.23.1777"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.442"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00467.x"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.10.945"},{"key":"e_1_2_11_39_2","first-page":"760","article-title":"Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains","volume":"73","author":"Peek RM","year":"1995","journal-title":"Lab Invest"},{"key":"e_1_2_11_40_2","first-page":"296","article-title":"Progress in defining the inflammatory cascade","volume":"7","author":"Figura N","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_11_41_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1128\/CDLI.7.5.803-809.2000","article-title":"Anti\u2010cagA immunoglobulin G responses correlate with interleukin\u20108 induction in human gastric mucosal biopsy culture","volume":"5","author":"Ando T","year":"2000","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_11_42_2","first-page":"878","article-title":"Histological and clinical predictive value of determination of tissue CagA status by PCR in Helicobacter pylori infected patients; results of the large population based study in western Turkey","volume":"49","author":"Saruc M","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609009126"},{"key":"e_1_2_11_44_2","first-page":"76","article-title":"The development of atrophic gastritis in antrum and body in relatives of gastritic carcinoma patients and in controls","volume":"31","author":"Kekki M","year":"1984","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_11_45_2","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/0016-5085(86)90908-X","article-title":"Progression of fundal gastritis in gastric ulcer patients","volume":"90","author":"Maaroos HI","year":"1986","journal-title":"Gastroenterology"},{"key":"e_1_2_11_46_2","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/iai.60.5.1946-1951.1992","article-title":"Identification and purification of a cpn60 heat shock protein homolog from Helicobacter pylori","volume":"60","author":"Dunn BE","year":"1992","journal-title":"Infection and Immunity."},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199800001-00007"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-48-10-927"},{"key":"e_1_2_11_49_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0016-5085(84)80009-8","article-title":"Specific and nonspecific humoral defence factors in the epithelium of normal and inflamed gastric mucosa","volume":"86","author":"Valnes K","year":"1984","journal-title":"Gastroenterology"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91716-H"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46882-0"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(99)80041-7"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.3.244"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050210"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.4.498"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(20000301)48:5<303::AID-JEMT7>3.0.CO;2-X"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80008-X"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750024515"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01286.x"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80012-1"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050344"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2008.00934.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2008.00934.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:05:13Z","timestamp":1697061913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2008.00934.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1111\/j.1600-0463.2008.00934.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2008.00934.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"2008-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}