{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:04:15Z","timestamp":1792724655729,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:00:00Z","timestamp":1218585600000},"content-version":"vor","delay-in-days":73,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Pancreatic duodenal homeobox 1 (PDX\u20101), a Hox type transcription factor, is necessary for differentiation of exocrine and endocrine pancreas, and regulates insulin gene transcription. PDX\u20101 expression was studied by immunohistochemistry on a tissue microarray (TMA) of 289 primary prostate cancers (PCa) from radical prostatectomy (RP) specimens with median follow\u2010up of 48.9 months. We separately arrayed benign prostatic tissue, atrophy, high\u2010grade prostatic intraepithelial neoplasia (HGPIN) and PCa from 40 men and also 17 lymph node metastases. Intensity and extent of immunoreactivity and their product (IRp) were evaluated by two independent observers. PDX\u20101 was overexpressed in cancer <jats:italic>vs<\/jats:italic> benign tissue (p&lt;0.001), but also in atrophy and HGPIN <jats:italic>vs<\/jats:italic> cancer (p&lt;0.001 and p=0.022, respectively). PDX\u20101 expression did not correlate with biochemical recurrence, but decreased with higher Gleason pattern (p&lt;0.001) and in metastases <jats:italic>vs<\/jats:italic> primary PCa (p&lt;0.001). Weighted kappa for interobserver agreement of intensity, extent and IRp was 0.65, 0.13 and 0.54, respectively. Presence of PDX\u20101 protein in benign and malignant prostatic tissue was confirmed by Western blot. In view of recent attention to the role of insulin systems in men with PCa, this protein is of interest in the pathogenesis of PCa.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2008.01020.x","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T14:59:29Z","timestamp":1218639569000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Expression of PDX\u20101 in prostate cancer, prostatic intraepithelial neoplasia and benign prostatic tissue"],"prefix":"10.1111","volume":"116","author":[{"given":"SARA","family":"JONMARKER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AXEL","family":"GLAESSGEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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